Immunologic Research

, Volume 33, Issue 3, pp 195–212

Regulatory T cell-mediated transplantation tolerance

Authors

  • Ankit Bharat
    • Department of SurgeryWashington University School of Medicine
  • Ryan Courtney Fields
    • Department of SurgeryWashington University School of Medicine
  • T. Mohanakumar
    • Department of SurgeryWashington University School of Medicine
    • Department of PathologyWashington University School of Medicine
Article

DOI: 10.1385/IR:33:3:195

Cite this article as:
Bharat, A., Fields, R.C. & Mohanakumar, T. Immunol Res (2005) 33: 195. doi:10.1385/IR:33:3:195

Abstract

The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

Key Words

Regulatory cellsLung transplantationTransplantation toleranceAdaptive immune responseInfectious toleranceT cellsAntigen presentation
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Copyright information

© Humana Press Inc. 2005