Regulatory T cell-mediated transplantation tolerance
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- Bharat, A., Fields, R.C. & Mohanakumar, T. Immunol Res (2005) 33: 195. doi:10.1385/IR:33:3:195
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The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.