Immunologic Research

, Volume 32, Issue 1, pp 231–245

Interferon-γ and cancer immunoediting

  • Gavin P. Dunn
  • Hiroaki Ikeda
  • Allen T. Bruce
  • Catherine Koebel
  • Ravi Uppaluri
  • Jack Bui
  • Ruby Chan
  • Mark Diamond
  • J. Michael White
  • Kathleen C. F. Sheehan
  • Robert D. Schreiber
Article

DOI: 10.1385/IR:32:1-3:231

Cite this article as:
Dunn, G.P., Ikeda, H., Bruce, A.T. et al. Immunol Res (2005) 32: 231. doi:10.1385/IR:32:1-3:231

Abstract

Over the last 12 yr, we have shown that interferony and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial “cancer immuno-surveillance” hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.

Key Words

Interferon-γcancerImmunosurveillancesignal transductio9ncancer immunoeditinglymphocytes

Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Gavin P. Dunn
    • 1
  • Hiroaki Ikeda
    • 1
  • Allen T. Bruce
    • 1
  • Catherine Koebel
    • 1
  • Ravi Uppaluri
    • 1
  • Jack Bui
    • 1
  • Ruby Chan
    • 1
  • Mark Diamond
    • 1
  • J. Michael White
    • 1
  • Kathleen C. F. Sheehan
    • 1
  • Robert D. Schreiber
    • 1
  1. 1.Department of Pathology and Immunology, Center for ImmunologyWashington University School of MedicineSt. Louis