Immunologic Research

, Volume 30, Issue 3, pp 261–277

C-reactive protein

An activator of innate immunity and a modulator of adaptive immunity
  • Terry W. Du Clos
  • Carolyn Mold

DOI: 10.1385/IR:30:3:261

Cite this article as:
Du Clos, T.W. & Mold, C. Immunol Res (2004) 30: 261. doi:10.1385/IR:30:3:261


C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcγ receptors (FcγR) have led to an increased appreciation of the regulatory role of CRP in inflammation and autoimmunity. This review outlines the role of CRP in infection, inflammation, and autoimmune disease. We provide a discription of recent studies, which suggest that CRP acts through FcγR to reduce inflammation and protect from certain autoimmune diseases. A general description of the proposed function of CRP is provided as a framework for future in vestigation.

Key words

C-reactive proteinAcute-phase responsePentraxinsAutoimmune miceInflammationFc receptorsLPSSLEComplement

Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  • Terry W. Du Clos
    • 1
    • 2
  • Carolyn Mold
    • 3
  1. 1.Department of Veterans Affairs Medical CenterAlbuquerque
  2. 2.School of Medicine Department of Internal MedicineThe University of New MexicoAlbuquerque
  3. 3.School of Medicine, Department of Molecular Genetics and MicrobiologyThe University of New MexicoAlbuquerque