Article

Immunologic Research

, Volume 28, Issue 3, pp 181-191

First online:

Antibody-induced transplantation tolerance

The role of dominant regulation
  • Luis GracaAffiliated withSir William Dunn School of Pathology, University of Oxford
  • , Alain Le MoineAffiliated withSir William Dunn School of Pathology, University of Oxford
  • , Stephen P. CobboldAffiliated withSir William Dunn School of Pathology, University of Oxford
  • , Herman WaldmannAffiliated withSir William Dunn School of Pathology, University of Oxford

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Abstract

A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy.

Key Words

Regulatory T cells CD4+CD25+ Therapeutic antibodies Infectious tolerance