Immunologic Research

, Volume 27, Issue 2, pp 149–159

Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens


DOI: 10.1385/IR:27:2-3:149

Cite this article as:
Caspi, R.R. Immunol Res (2003) 27: 149. doi:10.1385/IR:27:2-3:149


Our interests revolve around the study of biological mechanisms regulating self-tolerance to immunologically privileged retinal proteins that serve as targets in sight-threatening autoimmune uveitic disease. These studies are aimed at understanding how selftolerance to these antigens develops during ontogeny and is maintained during adulthood, the processes involved in its pathological breakdown, the regulatory mechanisms that bring about remission and recovery, and, finally, how we can utilize knowledge of these processes for therapeutic restoration of tolerance. To answer these questions, we use the experimental autoimmune uveitis (EAU) model in rats and mice. Because of the commonality of underlying immunological mechanisms, lessons and concepts learned in experimental ocular models are applicable to other disease entities, and, conversely, data gleaned from other autoimmune diseases are applicable to the study of uveitis.

Key Words

Uveitis Autoimmune disease T Cells Th1/Th2 Tolerance 

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  1. 1.Section on Immunoregulation, Laboratory of Immunology, National Eye InstituteNIHBethesda
  2. 2.Department of Pathology and Laboratory MedicineUniversity of PennsylvanniaPhiladelphia

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