Immunologic Research

, Volume 26, Issue 1, pp 143–152

STEALTH in transplantation tolerance

  • Anne Hutchings
  • William J. Hubbard
  • Frank T. Thomas
  • Judith M. Thomas
Article

DOI: 10.1385/IR:26:1-3:143

Cite this article as:
Hutchings, A., Hubbard, W.J., Thomas, F.T. et al. Immunol Res (2002) 26: 143. doi:10.1385/IR:26:1-3:143

Abstract

Although contemporary immunosuppressive regimens are responsible for major improvements in allograft acceptance, there are indications that long-term survival may be compromised through drug toxicity and/or chronic immune deficiency. The ultimate goal for transplantation is tolerance, defined as durable, donor-specific allograft acceptance in the absence of long-term immunosuppression. This article reviews the non human primante STEALTH model of tolerance recently developed by the transplant immunobiology group at University of Alabama at Birmingham. The STEALTH model was designed for future application to human transplantation and comprises a concise peritransplant treatment strategy of only 2 wk. Tolerance is induced by depletion of T cells, with concomitant inhibition of nuclear factor-KB/RelB-dependent proinflammatory signaling. This treatment has resulted in an unprecedented frequency of kidney allograft survival (62.5% at 3 yr), with some primate recipients remaining in good health more than 6 yr posttransplant, in the complete absence of chronic pharmacologic immunosuppression.

Key Words

ImmunosuppressionImmunotoxinIsletKidneyLymphocyteDepletionNonhuman primateTransplantation

Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Anne Hutchings
    • 1
  • William J. Hubbard
    • 1
  • Frank T. Thomas
    • 1
  • Judith M. Thomas
    • 1
  1. 1.Division of Transplantation Immunobiology, Department of SurgeryUniversity of Alabama at BirminghamBirmingham