Immunologic Research

, Volume 25, Issue 2, pp 97–113

Transcytosis and catabolism of antibody

  • Victor Ghetie
  • E. Sally Ward

DOI: 10.1385/IR:25:2:097

Cite this article as:
Ghetie, V. & Ward, E.S. Immunol Res (2002) 25: 97. doi:10.1385/IR:25:2:097


This review describes the evolution of our knowledge of the transmission of immunoglobulin G (IgG) from mother to infant and the factors which regulate the persistence of IgG in the circulation. These apparently unrelated processes involve the same Fc receptor, FcRn (n=neonatal). FcRn appears to carry out these diverse roles by binding to IgG and then either transporting the bound IgG across cells (transcytosis) or recycling its cargo back to the cell surface (control of catabolism). IgG that is taken up by cells in the absence of binding to FcRn undergoes degradation. Thus, FcRn is the “protective” receptor that servesto maintain IgG homeostasis and deliver IgGs across cellular barriers.

Key Words

TranscytosisCatabolismAntibodyImmunoglobulin GFc receptorNeonatal Fc receptor

Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Victor Ghetie
    • 1
  • E. Sally Ward
    • 1
    • 2
  1. 1.Cancer Immunobiology CenterUniversity of Texas Southwestern Medical CenterDallas
  2. 2.Center for ImmunologyUniversity of Texas Southwestern Medical CenterDallas