Endocrine

, Volume 26, Issue 1, pp 33–39

Ovulation block by Pueraria mirifica

A study of its endocrinological effect in female monkeys
  • Hataitip Trisomboon
  • Suchinda Malaivijitnond
  • Gen Watanabe
  • Kazuyoshi Taya
Original Articles

DOI: 10.1385/ENDO:26:1:033

Cite this article as:
Trisomboon, H., Malaivijitnond, S., Watanabe, G. et al. Endocr (2005) 26: 33. doi:10.1385/ENDO:26:1:033
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Abstract

Pueraria mirifica (PM), a Thai herb containing phytoestrogens, may act as estrogen and disturb reproduction. To investigate the effect of PM on the menstrual cycle length and related hormones, nine adult female monkeys (Macaca fascicularis) were separated into three groups. Each group (n=3) was fed with 10, 100, and 1000 mg/d of PM for three menstrual cycles. The menstrual cycle length increased significantly in monkeys treated with PM-10 and PM-100 and disappeared completely in monkeys treated with PM-1000. Serum follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and ir-inhibin were lower during the treatment period in a dose-dependent manner. Changes in menstrual cycle length and the hormonal levels recovered during the post-treatment period only in monkeys treated with PM-10 and PM-100. PM greatly influences menstrual cycles and may suppress ovulation by lowering serum levels of gonadotropins.

Key Words

Gonadotropins ovarian hormones phytoestrogens Pueraria mirifica cynomolgus monkey 

Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Hataitip Trisomboon
    • 1
    • 2
  • Suchinda Malaivijitnond
    • 2
  • Gen Watanabe
    • 3
    • 4
  • Kazuyoshi Taya
    • 3
    • 4
  1. 1.Department of Physiology, Faculty of MedicineSrinakharinwirot UniversityBangkokThailand
  2. 2.Primate Research Unit, Department of Biology, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  3. 3.Laboratory of Veterinary Physiology, Faculty of AgricultureTokyo University of Agriculture and TechnologyTokyoJapan
  4. 4.Department of Basic Veterinary Science, The United Graduate School of Veterinary ScienceGifu UniversityGifuJapan

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