Endocrine

, Volume 18, Issue 3, pp 285–293

Structural aspects of luteinizing hormone receptor

Information from molecular modeling and mutagenesis
Article

DOI: 10.1385/ENDO:18:3:285

Cite this article as:
Fanelli, F. & Puett, D. Endocr (2002) 18: 285. doi:10.1385/ENDO:18:3:285

Abstract

The luteinizing hormone receptor (LHR) is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimeric glycoprotein hormone family. This receptor is an essential component of the reproductive axis in males and females, and a number of naturally occurring pathophysiologic activating and inactivating mutations have been described. This review deals with the current state of knowledge of the structure of LHR based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations.

Key Words

Lutropin receptor G protein-coupled receptor molecular modeling mutagenesis luteinizing hormone receptor 

Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  1. 1.Delbecco Telethon Institute (DTI) and Department of ChemistryUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Department of Biochemistry & Molecular BiologyUniversity of GeorgiaAthens