Article

Cardiovascular Toxicology

, Volume 3, Issue 3, pp 219-228

First online:

Cell death and diabetic cardiomyopathy

  • Lu CaiAffiliated withDepartment of Medicine, University of Louisville School of Medicine Email author 
  • , Y. James KangAffiliated withDepartment of Medicine, University of Louisville School of MedicineDepartment of Pharmacology and Toxicology, University of LouisvilleJewish Hospital Heart and Lung Institute

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Abstract

Myocardial cell death is a key element in the pathogenesis and progression of various etiological cardiomyopathies such as ischemia-reperfusion, toxic exposure, and various chronic diseases including myocardial infarction, atherosclerosis, and endothelial dysfunction. Myocardial cell death is also observed in the hearts of diabetic patients and antimal models; however, its importance in the development of diabetic cardiomyopathy is not completely understood. The goal of this review is to summarize our current understanding of the characteristics of diabetes-induced myocardial cell death. In the search of themechanisms by which diabetes induces myocardial cell death, multiple cell death pathways have been proposed. Reactive oxygen and nitrogen species accumulation plays a critical role in the cell death by antioxidants or inhibitors for apoptosis-specific signaling pathways results in a significant prevention of diabetic cardiotoxicity, suggesting that cell death in diabetic subjects plays an important role in the development of diabetic cardiomyopathy.

Key words

Apoptosis hyperglycemia hyperlipidemia inflammation cytokines oxidative stress antioxidants