Clinical Reviews in Allergy & Immunology

, Volume 25, Issue 3, pp 259–274

Bronchiolitis obliterans

  • Petey Laohaburanakit
  • Andrew Chan
  • Roblee P. Allen
Article

DOI: 10.1385/CRIAI:25:3:259

Cite this article as:
Laohaburanakit, P., Chan, A. & Allen, R.P. Clinic Rev Allerg Immunol (2003) 25: 259. doi:10.1385/CRIAI:25:3:259

Abstract

Bronchiolitis obliterans (BO) is a disease of small airways that results in progressive dyspnea and airflow limitation. It is a common sequela of bone marrow, lung, and heart-lung transplantation, but can also occur as a complication of certain pulmonary infections, adverse drug reaction, toxic inhalation, and autoimmune disorders. Non-transplant-related BO is rare and can mimic asthma and chronic obstructive pulmonary disease (COPD). In transplant-related BO, the diagnosis can be suggested by obstructive changes in serial pulmonary function testings, while open lung biopsy is usually required in non-transplant cases. High-resolution computerized tomography (HRCT) is also a helpful tool to diagnose and assess the severity of BO. The treatment of BO, regarding of the cause, is usually disappointing. Systemic corticosteroid immunosuppression and retransplantation have been described with variable success.

Index Entries

Bronchiolitis bronchiolitis obliterans constrictive bronchiolitis small airway obstruction interstitial lung disease 

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Petey Laohaburanakit
    • 1
  • Andrew Chan
    • 1
  • Roblee P. Allen
    • 1
  1. 1.Division of Pulmonary and Critical Care, Department of Internal MedicineUniversity of CaliforniaDavis

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