Cell Biochemistry and Biophysics

, Volume 46, Issue 1, pp 43–64

The α-aminoadipate pathway for lysine biosynthesis in fungi


DOI: 10.1385/CBB:46:1:43

Cite this article as:
Xu, H., Andi, B., Qian, J. et al. Cell Biochem Biophys (2006) 46: 43. doi:10.1385/CBB:46:1:43


This review provides a description of the biochemistry and enzymology of the α-aminoadipate pathway for lysine biosynthesis in fungi. The α-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.

Index Entries

α-Aminoadipate pathwaylysine biosynthesis in fungihomocitrate synthaseClaisen condensationα-aminoadipate reductasesaccharopine reductasesaccharopine dehydrogenasepyridine nucleotide-linked amino acid oxidoreductaseantifungal drugs

Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of OklahomaNorman