Review Article

Cell Biochemistry and Biophysics

, Volume 43, Issue 3, pp 439-449

Cytoskeletal regulation of nitric oxide synthase

  • Yunchao SuAffiliated withDepartment of Medicine, University of Florida Email author 
  • , Dmitry KondrikovAffiliated withDepartment of Medicine, University of Florida
  • , Edward R. BlockAffiliated withDepartment of Medicine, University of FloridaResearch Service, Malcolm Randall Veterans Affairs Medical Center

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Abstract

The three isoforms of nitric oxide synthase (NOS)—endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS)—colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

Index Entries

Actin microtubules intermediate filaments endothelium transcription