Imaging glucose-regulated insulin secretion and gene expression in single islet β-cells
- Cite this article as:
- Rutter, G.A., Leclerc, I., Tsuboi, T. et al. Cell Biochem Biophys (2004) 40(Suppl 3): 179. doi:10.1385/CBB:40:3:179
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The mechanisms by which changes in glucose concentration regulate gene expression and insulin secretion in pancreatic islet β-cells are only partly understood. Here we describe the development of new technologies for examining these processes at the level of single living β-cells. We also present recent findings, made using these and other techniques, which implicate a role for adenosine 5′-monophosphate-activated protein kinase in glucose signaling in these cells.