Review Article

Cell Biochemistry and Biophysics

, Volume 36, Issue 2, pp 235-239

First online:

Molecular and cellular characterization of transferrin receptor 2

  • V. Nathan SubramaniamAffiliated withMembrane Transport Laboratory, Queensland Institute of Medical ResearchUniversity of Queensland Email author 
  • , Lesa SummervilleAffiliated withMembrane Transport Laboratory, Queensland Institute of Medical Research
  • , Daniel F. WallaceAffiliated withMembrane Transport Laboratory, Queensland Institute of Medical Research

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Abstract

Iron is an essential component of many biological processes. However, an excess of iron in the body is also toxic; thus, the levels of this element are tightly regulated. Our knowledge of the mechanism by which iron levels are maintained has been bolstered by the dramatic increase in the discovery of novel molecules implicated in iron homeostasis. The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron. The recently identified homolog of transferrin receptor, its characterization and its role in iron metabolism is the subject of this review.

Index Entries

Iron transport liver transferrin receptor hemochromatosis HFE