Cell Biochemistry and Biophysics

, Volume 36, Issue 2, pp 235–239

Molecular and cellular characterization of transferrin receptor 2

Authors

    • Membrane Transport LaboratoryQueensland Institute of Medical Research
    • University of Queensland
  • Lesa Summerville
    • Membrane Transport LaboratoryQueensland Institute of Medical Research
  • Daniel F. Wallace
    • Membrane Transport LaboratoryQueensland Institute of Medical Research
Review Article

DOI: 10.1385/CBB:36:2-3:235

Cite this article as:
Subramaniam, V.N., Summerville, L. & Wallace, D.F. Cell Biochem Biophys (2002) 36: 235. doi:10.1385/CBB:36:2-3:235

Abstract

Iron is an essential component of many biological processes. However, an excess of iron in the body is also toxic; thus, the levels of this element are tightly regulated. Our knowledge of the mechanism by which iron levels are maintained has been bolstered by the dramatic increase in the discovery of novel molecules implicated in iron homeostasis. The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron. The recently identified homolog of transferrin receptor, its characterization and its role in iron metabolism is the subject of this review.

Index Entries

Iron transportlivertransferrin receptorhemochromatosisHFE

Copyright information

© Humana Press Inc. 2002