Blood and tissue concentration of cesium after exposure to cesium chloride
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Context: Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy have not been approved by the U.S. Food and Drug Administration (FDA).
Objective: Cesium (Cs) levels from human tissue were measured to determine exposure to an alternative medical treatment. Cesium levels are reported from two patients who were administered cesium chloride in conjunction with aloe vera as part of an alternative cancer treatment.
Design: The samples were analyzed by graphite furnace atomic absorption spectrometry with Zeeman background correction. As a reference, Cs was also determined in brain, liver, kidney, and whole blood from control case materials retrieved from the National Tissue Repository of the Armed Forces Institute of Pathology.
Results: High levels of cesium were found in brain, liver, kidney, bile, gastric content, and whole blood collected at autopsy as compared to reference levels. The administration of cesium chloride resulted in blood levels a factor of 1100 higher than normal. The highest Cs concentrations were found in the liver (1029 µg/g, dry wt), followed by the kidney (815 µg/g, dry wt) and brain (219 µg/g, dry wt).
Conclusion: The high accumulation in the liver suggests that hepatotoxicity from Cs might be an initial presenting symptom in Cs-poisoning cases. This is the first report describing two cases with high Cs levels in human tissues.
- W. Jonas, Alternative medicine and the conventional practitioner. JAMA 279, 708–709 (1998). CrossRef
- M. Angell and J.P. Kassirer, Alternative medicine—The risks of untested and unregulated remedies. N. Eng. J. Med. 339, 839–841 (1998). CrossRef
- W.B. Jonas, Y. Lin, A. Williams, R. Tortella, and R. Tuma, Treatment of experimental stroke with low-dose glutamate and homeopathic Arnica Montana. Perfusion 12, 452–462 (1999).
- E.R. Braverman, A. Sohler, and C.C. Pfeiffer, Cesium chloride: preventive medicine for radioactive cesium exposure? Med Hypothesis 26, 93–95 (1988). CrossRef
- H.E. Sartori, Cesium therapy in cancer patients. Pharmacol. Biochem. Behav. 21(1 suppl), 11–13 (1984). CrossRef
- K.A. Brewer, The high pH therapy for cancer tests on mice and humans. Pharmacol. Biochem. Behav. 21(1 suppl), 1–5 (1984). CrossRef
- R. Neulieb, Effects of oral intake of cesium chloride, a single case report. Pharmacol. Biochem. Behav. 21(1 suppl), 15–16 (1984). CrossRef
- F.W. Tufte and M.J. Tufte, The effects of zinc gluconate, vitamin A and cesium salts on colon carcinoma in mice. Cytobios 39, 177–182 (1984).
- H.E. Sartori, Nutrients and cancer: an introduction to cesium therapy. Pharmacol. Biochem. Behav. 21(1 suppl), 7–10 (1984). CrossRef
- F.S. Messiha, Effect of cesium and ethanol on tumor bearing rats. Pharmacol. Biochem. Behav. 21(1 suppl), 35–40 (1984). CrossRef
- A. Pinter, P. Dorian, and D. Newman, Cesium-induced Torsades de Pointes. N. Engl. J. Med. 346, 383–384 (2002). CrossRef
- W. Saliba, O. Erdogan, and M. Niebauer, Polymorphic ventricular tachycardia in a woman taking cesium chloride. Pacing Clin. Electrophysiol. 24, 515–517 (2001). CrossRef
- A. Ghosh, A. Sharma, and G. Talukder, Effects of cesium on cellular systems. Biol. Trace Elem. Res. 38, 165–193 (1993).
- D. Pearson, Whole body cesium levels in man. Health Phys. 45, 167–169 (1983).
- D. Gawlik, D. Behne, D. Kraft, and G. Offermann, The influence of renal insufficiency on cesium metabolism in man and rat (with a note on the Cs content of some biological standard materials). J. Trace Elem. Electrolytes Health Dis. 3, 43–50 (1989).
- F.S. Messiha, Developmental toxicity of cesium in the mouse. Gen. Pharmacol. 25, 395–400 (1994).
- K. Nikula, B.A. Muggenburg, I. Chiang, W.C. Griffith, F.F. Hahn, and B.B. Boecker, Biological effects of 137CsCl injected in beagle dogs. Radiat Res. 142, 347–361 (1995). CrossRef
- J. Versieck and R. Cornelius, Normal levels of trace elements in human blood plasma or serum. Anal. Chim. Acta 116, 217–254 (1980). CrossRef
- P. Bratter, D. Gawlik, P. Klingbeil, C. Koppel, and U. Rosick, Blood and tissue concentration of trace elements after fatal intoxication with cadmium chloride, in Metal Ions in Biology and Medicine; vol 5. P. Collery, V. Bratter, N. De Bratter, L. Khassanova, and J.C. Etienne, eds., John Libbey Eurotext, Paris 1998, pp 309–314.
- Report of the task group on reference man. ICRP Publication 23 1975. Oxford, England.
- J.W. Gofman, O.F. DeLalla, E.I. Kovich, et al. Chemical elements in the blood of man. Arch. Envir. Health 8, 113–120 (1964).
- F.F. Hahn, B.A. Muggenburg, and B.B. Boecker, Hepatic neoplasms from internally deposited 144CeCl3. Toxicol. Pathol. 24, 281–289 (1996). CrossRef
- Blood and tissue concentration of cesium after exposure to cesium chloride
Biological Trace Element Research
Volume 94, Issue 2 , pp 97-104
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press
- Additional Links
- Cesium chloride
- cesium blood and tissue levels
- alternative medicine
- Industry Sectors
- Author Affiliations
- 1. Department of Environmental and Toxicologic Pathology, Armed Forces Institute of Pathology, 20306, Washington DC
- 2. Northern Virginia, 22032, Fairfax, VA
- 3. Office of the Armed Forces Medical Examiner’s, Armed Forces Institute of Pathology, 20306, Washington, DC