Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma
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The aim of this study is to investigate the relationship between trace elements and the incidence of cervical cancer. Tissue and serum levels of six elements (Cu, Zn, Fe, Mn, Ca, and Se) and the Cu/Zn ratio in 40 cases of patients with cervical cancer, 30 cases of uterine myoma, and 50 healthy subjects were measured by atomic absorption spectrophotometry; the selenium content was determined by atomic fluorescence spectrometry. The results showed that the tissue contents of Zn, Se, and Ca were significantly lower and the Cu and Fe concentrations and Cu/Zn ratio were significantly higher in cervical cancer tissue than that for paired nonlesion tissue (p<0.02 and p<0.001, respectively). The serum levels of Zn, Se, Ca, and Fe were lower and Cu and Mn levels and Cu/Zn ratio were higher in patients with cervical cancer than in healthy subjects (p<0.01 and p<0.001, respectively) and in the uterine myoma group compared with healthy subjects (p< 0.05–0.001). There are no significant differences in the contents of six elements and the Cu/Zn ratio between uterine myoma tissue and paired nonlesion tissue. The results showed also that the Fe level and Cu/Zn ratio were significantly higher and the Zn and Se levels were significantly lower in cervical cancer tissue than in uterine myoma tissue (p<0.01 and p<0.001, respectively). The serum Cu level and Cu/Zn ratio were significantly higher in the cervical cancer group than the uterine myoma group (p<0.01). Data were also analyzed using multivarate logistic regression. After adjustment for age, occupation, life habit, and other covariates for the development of cervical cancer, the odds ratios were 22.64 (95% confidence interval [CI]: 5.64–90.88, p=0.001) for Cu, 0.11 (95% CI: 0.034–0.373; p=0.005) for Zn, and 0.60 (95% CI: 0.36–0.99, p=0.01) for Se. Thus, the serum and tissue levels of Cu increase and the deficiency of Zn and Se may be risk factors for the development of cervical cancer.
- W. G. Li, Q. S. Huang, S. Y. Yu, et al., Six-year prospective observation on ingesting selenium-salt to prevent primary liver cancer, Chin. J. Cancer 12, 108–110 (1993).
- Y. J. Zhang, J. X. Jing, C. Z. Han, et al., Impairment of antioxidant system in human esophageal cancer, Chin. J. Exp. Surg. 19, 182–183 (2002).
- N. Manuel, G. Ander, R. Gilles, et al., Urinary selenium excretion in patients with cervical uterine cancer, Biol. Trace Element Res. 79, 97–105 (2001). CrossRef
- J. V. Selby and G. D. Friedman, Epidemiologic evidence of an association between body iron store and risk of cancer, Int. J. Cancer 44, 677–682 (1988). CrossRef
- L. A. Van Asperen, E.J.M. Feskens, C. H. Bowles, et al., Body iron stores and mortality due to cancer and ischemic heart disease: a 17-year follow-up study of elderly men and women, Int. J. Epidemiol. 24, 665–670 (1995). CrossRef
- J. I. Wurzermann, A. Silver, D. M. Schreinemachers, et al., Iron intake and risk of colorectal cancer, Cancer Epidemiol. Biomarkers Prev. 15, 503–507 (1996).
- X. W. Zhao, C. Z. Han, et al., Relationship of serum trace elements to lung cancer and clinical application, Chin. J. Epidemiol. 19, 286–290 (1998).
- H. Y. Wu, L. Y. Yu, L. G. Xu, et al., Clinical study on serum copper, zinc levels and copper/zinc ratio in malignant lymphoma, Chin. J. Oncol. 10, 335–337 (1988).
- M. David, N. Ondrer, S. Vaclan, et al., Serum levels of selenium, manganese, copper and iron in colorectal cancer patients, Biol. Trace Element Res. 79, 107–114 (2001). CrossRef
- C. Z. Han, J. X. Jing, et al., Relationship between trace elements in hair and esophageal cancer, Acta Nutr. Sin. 17, 431–433 (1995).
- C. Z. Han, X. B. Liang, W. Su, et al., Study on the association and significance between trace elements and rectal cancer, Chin J. Epidemiol. 20, 166–169 (1999).
- M. L. Slattery, A. W. Sovenson, and M. H. Ford, Dietary calcium intake as a mitigating factor in colon cancer, Am. J. Epidemiol. 128, 504–513 (1988).
- G. Yang, Y. T. Gao, B. T. Ji, et al., A case-control study on colorectal cancer and dietary fiber and calcium of various sources, Chin. J. Met. Prev. 28, 195–198 (1994).
- L. Wang, S. L. Qu, et al., Effect of added dietary calcium on human esophageal cancer, Chin. J. Tumor 12, 332–335 (1994).
- A. Chan, F. Wong, and M. Arumanayagam, Serum ultrafiltrable copper, total copper and ceruloplasmin concentrations in gynecological carcinomas, Ann. Clin. Biochem. 30, 545–549 (1993).
- M. Zowczak, M. Iskra, L. Torimski, et al., Analysis of serum copper and zinc concentrations in cancer patients, Biol. Trace. Element Res. 82, 1–8 (2001). CrossRef
- Y. Y. Cheng, C. Z. Han, J. X. Jing, et al., The correlation of trace elements with ovarian cancer and clinical application value, J. Shanxi Med. 26, 493–495 (1997).
- C. Z. Han, J. X. Jing, et al., Classification and prognostic value of serum copper/zinc ratio in hodgkin’s disease, Biol. Trace Element Res. 83, 133–138 (2001). CrossRef
- J. Machacek, P. Mensik, and V. Bicik, Serum levels of copper and zinc in breast cancer and its possible using in clinical practice, New Clin. Oncol. 6, 112–116 (1984).
- A. S. Prasad, Zinc in human health: an update, Trace Elements Exp. Med. 11, 63–87 (1998). CrossRef
- P. M. Newberne, T. F. Schrager, and S. Broitman, Esophageal carcinogenesis in the rat: zinc deficiency and alcohol effects on tumor inductions, Pathobiology 65, 39–45 (1997). CrossRef
- M. Sciezska, A. Danch, M. Machalski, et al., Plasma selenium concentration in patients with stomach and colon cancer in the upper Silesia, Neoplasma 44, 395–397 (1997).
- D. Psathakis, N. Wedemyer, E. Oevermann, et al., Blood selenium and gluthathione peroxidase status in patients with colorectal cancer, Dis. Colon Rectum 41, 328–335 (1998). CrossRef
- V. Singh and A. N. Garg, Trace element correlations in the blood of Indian women with breast cancer, Biol. Trace Element Res. 64, 237–245 (1998).
- I. Kato, A. M. Dnistrian, M. Schwartz, et al., Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study, Int. J. Cancer. 80, 693–698 (1999). CrossRef
- A. C. Chua and E. H. Morgan, Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol. Trace Element Res. 55, 39–54 (1996). CrossRef
- Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma
Biological Trace Element Research
Volume 94, Issue 2 , pp 113-122
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press
- Additional Links
- Cervical cancer
- uterine myoma
- trace element
- Industry Sectors
- Author Affiliations
- 1. Department of Etiology, Shanxi Cancer Institute, 030013, Taiyuan, People’s Republic of China
- 2. Department of Gynecology, Shanxi Tumor Hospital, 030013, Taiyuan, People’s Republic of China