Biological Trace Element Research

, 82:1

Analysis of serum copper and zinc concentrations in cancer patients

  • Miłosława Zowczak
  • Maria Iskra
  • Lech Torliński
  • Szczepan Cofta
Article

DOI: 10.1385/BTER:82:1-3:001

Cite this article as:
Zowczak, M., Iskra, M., Torliński, L. et al. Biol Trace Elem Res (2001) 82: 1. doi:10.1385/BTER:82:1-3:001

Abstract

Several studies have shown that plasma copper concentrations are increased in various carcinomas. Zinc acts as a cellular growth protector, including growth of neoplastic cells, and its deficiency was demonstrated to be involved in several stages of malignant transformation. However, the usefulness of the serum zinc and copper determinations in cancer prevention, detection, monitoring treatment, and prognosis requires further investigations. The aim of the present study was to compare the serum copper and zinc levels in patients with cancer of the lung (PC), breast (BC), gastrointestinal tract (GIC), and gynecological (GYNC) malignancy with progress of the disease. The results of the study have shown a significant increase in the mean total serum Cu levels and the serum Cu/Zn ratio in all patient groups with cancer compared to a control group. Increased mean serum concentrations and Cu/Zn ratios were found in the whole group (ALLC), and for the GIC and GYNC groups with local as well as metastasized (Meta) disease in comparison with the control group. The mean serum concentrations of Zn were decreased only in metastasized ALLC and GYNC groups.

Index Entries

Copperzincserumcanceroncogenesisbreastlunggastrointestinalgynecological

Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Miłosława Zowczak
    • 1
  • Maria Iskra
    • 1
  • Lech Torliński
    • 1
  • Szczepan Cofta
    • 2
  1. 1.Clinical BiochemistryKarol Marcinkowski University of Medical SciencesPoznańPoland
  2. 2.Department of PneumonologyKarol Marcinkowski University of Medical SciencesPoznańPoland