Biological Trace Element Research

, Volume 107, Issue 1, pp 1–9

Significance of serum trace element status in patients with rheumatic heart disease

A prospective study

Authors

    • Department of CardiologyInonu University, Faculty of Medicine, Turgut Ozal Medical Center
  • Ibrahim Sahin
    • Department of Internal MedicineInonu University, Faculty of Medicine, Turgut Ozal Medical Center
  • Nusret Acikgöz
    • Department of CardiologyInonu University, Faculty of Medicine, Turgut Ozal Medical Center
  • Yuksek Aksoy
    • Department of CardiologyInonu University, Faculty of Medicine, Turgut Ozal Medical Center
  • Zehra Kucukbay
    • Department of Analytical ChemistryInonu University, Faculty of Medicine, Turgut Ozal Medical Center
  • Sengul Cehreli
    • Department of CardiologyInonu University, Faculty of Medicine, Turgut Ozal Medical Center
Original Articles

DOI: 10.1385/BTER:107:1:001

Cite this article as:
Kosar, F., Sahin, I., Acikgöz, N. et al. Biol Trace Elem Res (2005) 107: 1. doi:10.1385/BTER:107:1:001

Abstract

It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59 μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease.

Index Entries

Rheumatic heart diseasetrace elementseleniumzinccopper

Copyright information

© Humana Press Inc 2005