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Regulatory T cell-mediated transplantation tolerance

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Abstract

The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

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Author notes

  1. T. Mohanakumar PhD

    Present address: Department of Surgery, Washington University School of Medicine, CSRB, 660 S Euclid Avenue, Box 8109-3328, 63110, St. Louis, MO

Authors and Affiliations

  1. Department of Surgery, Washington University School of Medicine, CSRB, 660 S Euclid Avenue, Box 8109-3328, 63110, St. Louis, MO

    Ankit Bharat & Ryan Courtney Fields

  2. Department of Pathology, Washington University School of Medicine, 63110, St. Louis, MO

    T. Mohanakumar PhD

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  1. Ankit Bharat
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  2. Ryan Courtney Fields
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  3. T. Mohanakumar PhD
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AB and RCF contributed equally to this work

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Bharat, A., Fields, R.C. & Mohanakumar, T. Regulatory T cell-mediated transplantation tolerance. Immunol Res 33, 195–212 (2005). https://doi.org/10.1385/IR:33:3:195

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