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C-reactive protein

An activator of innate immunity and a modulator of adaptive immunity

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Abstract

C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcγ receptors (FcγR) have led to an increased appreciation of the regulatory role of CRP in inflammation and autoimmunity. This review outlines the role of CRP in infection, inflammation, and autoimmune disease. We provide a discription of recent studies, which suggest that CRP acts through FcγR to reduce inflammation and protect from certain autoimmune diseases. A general description of the proposed function of CRP is provided as a framework for future in vestigation.

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  1. Terry W. Du Clos

    Present address: Department of Veterans Affairs Medical Center, Research Service 151, 1501 San Pedro S.E., 87 108, Albuquerque, NM

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  1. School of Medicine Department of Internal Medicine, The University of New Mexico, Albuquerque, NM

    Terry W. Du Clos

  2. School of Medicine, Department of Molecular Genetics and Microbiology, The University of New Mexico, Albuquerque, NM

    Carolyn Mold

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Du Clos, T.W., Mold, C. C-reactive protein. Immunol Res 30, 261–277 (2004). https://doi.org/10.1385/IR:30:3:261

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