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Antibody-induced transplantation tolerance

The role of dominant regulation

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Abstract

A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy.

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  1. Luis Graca

    Present address: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

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  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

    Alain Le Moine, Stephen P. Cobbold & Herman Waldmann

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  1. Luis Graca
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Graca, L., Le Moine, A., Cobbold, S.P. et al. Antibody-induced transplantation tolerance. Immunol Res 28, 181–191 (2003). https://doi.org/10.1385/IR:28:3:181

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