Abstract
The main characteristics of type 1 diabetic cardiomyopathy include depressed contractility and altered electrophysiological properties in ventricular myocytes. The goal of the present study was to determine the potential influence of gender in the diabetes-induced pathogenesis of ventricular myocyte function. Diabetes in both male and female rats was induced by a single intravenous injection of streptozotocin (STZ). Diabetic rats exhibited hyperglycemia and reduced body weight gain in both male and female groups. Neither contractile profiles nor activity of three types of K+ channels of ventricular myocytes was significantly different between nondiabetic male and female rats. Ventricular myocytes isolated from diabetic rats exhibited significant depresion in cell contraction and relaxation, which was associated with depression of intracellular Ca2+ ([Ca2+]i) transient. The degrees of contractile depression were comparable in ventricular myocytes obtained from both male and female diabetic rats. Similarly, diabetes depressed three types of outward K+ currents (Ito, Ik, and iss) to the same extent in both gender myocytes. These data demonstrate that in this animal model of diabetes, gender difference in cardiac myocyte functions was eliminated.
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Pierce, G. N. and Russell, J. C. (1997). Cardiovasc. Res. 34, 41–47.
Yu, J. Z., Rodrigues, B., and McNeill, J. H. (1997). Cardiovasc. Res. 34, 91–98.
Yu, Z., Quamme, G. A., and McNeill, J. H. (1994). Am. J. Physiol. 266, H2334-H2342.
Fein, F. S., Kornstein, L. B., Strobeck, J. E., Capasso, J. M., and Sonnenblick, E. H. (1980). Cric. Res. 47, 922–933.
Fein, F. S. and Sonnenblick, E. H. (1985). Prog. Cardiovasc. Dis. 27, 255–270.
Malhotra, A., Mordes, J. P., McDermott, L., and Schaible, T. F. (1985). Am. J. Physiol. 249, H1051-H1055.
Rodrigues, B. and McNeill, J. H. (1990). Canad. J. Physiol. Pharamcol. 68, 514–518.
Wold, L. E., Relling, D. P., Colligan, P. B., et al. (2001). J. Mol. Cell. Cardiol. 33, 1719–1726.
Choi, K. M., Zhong, Y., Hoit, B. D., et al. (2002). Am. J. Physiol. 283, H1398-H1408.
Stromberg, A. and Martensson, J. (2003). Eur. J. Cardiovasc. Nur. 2, 7–18.
Casis, O., Gallego, M., Iriarte, M., and Sanchez-Chapula, J. A. (2000). Diabetologia 43, 101–109.
Qin, D., Huang, B., Deng, L., et al. (2001). Biochem. Biophys. Res. Commun. 283, 549–553.
Xu, Z., Patel, K. P., Lou, M. F., and Rozanski, G. J. (2002). Cardiovasc. Res. 53, 80–88.
Casis, O., and Echevarria, E. (2004). Curr. Vasc. Pharmacol. 2, 237–248.
Farhat, M. Y., Lavigne, M. C., and Ramwell, P. W. (1996). FASEB J. 10, 615–624.
Bauters, C., Lamblin, N., McFadden, E., Van Belle, E., Millaire, A., and de Groote, P. (2003). Cardiovasc. Diabetol. 2, 1.
Suys, B. E., Katier, N., Rooman, R. P. A. et al. (2004). Diabetes Care 27, 1947–1953.
Zhong, J., Hwang, T. C., Adams, H. R., and Rubin, L. J. (1997). Am. J. Physiol. 273, H2312–2324.
Sperelakis, N., Xiong, Z., Haddad, G., and Masuda, H. (1994). Mol. Cell. Biochem. 140, 103–117.
McGrogan, I., Lu, S., Hipworth, S., et al. (1995). Am. J. Physiol. 268, L407-L413.
Schaible, T. F. and Scheuer, J. (1984). Basic Res. Cardiol. 79, 402–412.
Capasso, J. M., Remily, R. M., Smith, R. H., and Sonnenblick, E. H. (1983). Basic Res. Cardiol. 78, 156–171.
Brown, R. A., Walsh, M. F., and Ren, J. (2001). Endocr. Res. 27, 399–408.
Leblanc, N., Chartier, D., Gosselin, H., and Rouleau, J. L. (1998). J. Physiol. 511, 533–548.
Ho, K. K., Anderson, K. M., Kannel, W. B., Grossman, W., and Levy, D. (1993). Circulation 88, 107–115.
Schocken, D. D., Arrieta, M. I., Leaverton, P. E., and Ross, E. A. (1992). J. Am. Coll. Cardiol. 20, 301–306.
Curl, C. L., Wendt, I. R., and Kotsanas, G. (2001). Pflugers Arch. 441, 709–716.
Barrett-Connor, E. and Bush, T. L. (1991). JAMA. 265, 1861–1867.
Collins, P., Rosano, G. M., Jiang, C., Lindsay, D., Sarrel, P. M., and Poole-Wilson, P. A. (1993). Lancet 341, 1264–1265.
Grohe, C., Kahlert, S., Lobbert, K., et al. (1997). FEBS Lett. 416, 107–112.
Meyer, R., Linz, K. W., Surges, R., et al. (1998). Exp. Physiol. 83, 305–321.
Sowers, J. R. (1998). Arch. Intern. Med. 158, 617–621.
Ren, J. and Ceylan-Isik, A. F. (2004). Endocrine 25, 73–84.
Zhang, X., Ye, G., Duan, J., Chen, A. F., and Ren, J. (2003). Endocr. Res. 29, 227–236.
Shimoni, Y. and Liu, X. F. (2003). J. Physiol. 550, 401–412.
Shimoni, Y. and Liu, X. F. (2004). Am. J. Physiol. 287, H311-H319.
Makino, A., Oda, S., and Kamata, K. (2001). Peptides 22, 639–645.
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Ding, Y., Zou, R., Judd, R.L. et al. Effects of gender difference on cardiac myocyte dysfunction in streptozotocin-induced diabetic rats. Endocr 29, 135–141 (2006). https://doi.org/10.1385/ENDO:29:1:135
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DOI: https://doi.org/10.1385/ENDO:29:1:135