Obesity Surgery

, Volume 15, Issue 10, pp 1463–1468

Alterations in T-Cell Subset Frequency in Peripheral Blood in Obesity

  • Authors
  • Robert W O'Rourke
  • Thomas Kay
  • Mark H Scholz
  • Brian Diggs
  • Blair A Jobe
  • David M Lewinsohn
  • Antony C Bakke
Article

DOI: 10.1381/096089205774859308

Cite this article as:
O'Rourke, R.W., Kay, T., Scholz, M.H. et al. OBES SURG (2005) 15: 1463. doi:10.1381/096089205774859308

Background: Obesity affects the regulation of immune and inflammatory responses. This study characterizes differences in peripheral blood lymphocyte phenotype in obese humans. Methods: Frequencies of lymphocyte subsets among peripheral blood mononuclear cells were compared between 10 obese (BMI ≥35) and 10 lean subjects, as determined by antibodies directed against cluster differentiation (CD) markers. Results: Obese patients demonstrated an increased frequency of CD3+CD4+ T-cells (mean difference 12%, P=0.004), a decreased frequency of CD3+CD8+ T-cells (mean difference 9.4%, P=0.016) and an increased frequency of CD3+CD8+CD95+ T-cells (mean difference 13.3%, P=0.032). No other differences among T-cell or monocyte subsets were noted. Conclusions: Obesity is associated with alterations in frequencies of peripheral CD4+ and CD8+ T-cells and aberrations in the expression of CD95 among CD8+ T-cells. These data suggest both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95 expression on CD8+ T-cells, as targets for further study into obesity's effects on the immune system.

MORBID OBESITYFLOW CYTOMETRYLYMPHOCYTET-CELLIMMUNITY

Copyright information

© Springer 2005