Obesity Surgery

, Volume 13, Issue 3, pp 347–349

Prevalence of Non-alcoholic Steatohepatitis in Morbidly Obese Subjects Undergoing Gastric Bypass

  • Laurie Spaulding
  • Thomas Trainer
  • Dorota Janiec

DOI: 10.1381/096089203765887633

Cite this article as:
Spaulding, L., Trainer, T. & Janiec, D. OBES SURG (2003) 13: 347. doi:10.1381/096089203765887633

Background: Obesity is the most common cause of non-alcoholic steatohepatitis (NASH). This is a prospective study to determine the incidence and severity of NASH in patients undergoing Roux-en-Y gastric bypass (RYGBP) for morbid obesity. We also examined the relationship between NASH and potential risk factors. Methods: In 48 consecutive patients at RYGBP, a core liver biopsy was obtained from the left lateral segment. A single liver pathologist reviewed the histology for steatosis, ballooning/disarray, necroinflammation, and fibrosis. Results: 84% of patients were female, and average BMI was 51. 18% had WHR >1. The following risk factors were present: DM 16%; hyperlipidemia 61%; HTN 47%; and abnormal LFTs 18%. 90% had abnormal liver histology, and 56% qualified for the diagnosis of NASH. Only DM and abnormal LFTs were found to be significantly related to NASH. Conclusions: NASH is a common co-morbidity of obesity and requires systemized grading and staging to develop accurate knowledge of the incidence, severity, natural history and impact of weight loss.


Copyright information

© Springer 2003

Authors and Affiliations

  • Laurie Spaulding
    • Thomas Trainer
    • Dorota Janiec

    There are no affiliations available