Obesity Surgery

, Volume 12, Issue 1, pp 49–51

Liver Pathology in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass Surgery

  • Pierre M Gholam
  • Donald P Kotler
  • Louis J Flancbaum
Article

DOI: 10.1381/096089202321144577

Cite this article as:
Gholam, P.M., Kotler, D.P. & Flancbaum, L.J. OBES SURG (2002) 12: 49. doi:10.1381/096089202321144577

Background: Non-alcoholic fatty liver disease is common. However,little is known about liver disease in the morbidly obese. Methods: 75 subjects (78% female, mean BMI 57 [40-108]) who had intra-operative liver biopsies at the time of Roux-en-Y gastric bypass surgery were studied. Results: 84% of subjects had steatosis while only about 20% had moderate to severe inflammation and fibrosis. 8% had bridging fibrosis or cirrhosis. The presence of fibrosis correlated strongly with the presence of inflammation (p<0.001) and steatosis (p=0.0011), but weakly with ALT (p=0.02) and not with AST (p= 0.12) or with BMI (p=0.34). Steatosis correlated with AST (p=0.04) and ALT (p=0.055), but not with BMI. Conclusion: Liver disease is not rare in the morbidly obese. The exact causes and mechanisms that lead from the very common isolated steatosis to inflammation and fibrosis remain unclear. Intra-operative liver biopsies during bariatric surgery may be helpful to screen for the presence of steatohepatitis and fibrosis.

MORBID OBESITY LIVER STEATOSIS STEATOHEPATITIS BARIATRIC SURGERY 

Copyright information

© Springer 2002

Authors and Affiliations

  • Pierre M Gholam
    • Donald P Kotler
      • Louis J Flancbaum

        There are no affiliations available