, Volume 62, Issue 7-8, pp 441-445
Date: 23 Sep 2005

Enantioseparation of Some Clinically Used Drugs by Capillary Electrophoresis Using Sulfated β-Cyclodextrin as a Chiral Selector

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The enantiomeric separation of 37 clinically used racemic basic drugs among 50 drugs was achieved using sulfated β-cyclodextrin (S-β-CD) as chiral selector at pH2.5 and in the reversed polarity mode. The results obtained in this study were different from the one obtained using neutral β-CD and its derivatives as chiral selectors. Using S-β-CD as chiral selector did not require the presence of the substructure 4H to achieve chiral separation as observed with β-Cyclodextrin (β-CD) and its derivatives since among the 37 separated drugs only 7 possess the 4H substructure. The chiral discrimination depends on the appropriate interaction between the analyte and the sulfated β-cyclodextrin.