Enantioseparation of Some Clinically Used Drugs by Capillary Electrophoresis Using Sulfated β-Cyclodextrin as a Chiral Selector
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- Yang, G.S., Chen, D.M., Yang, Y. et al. Chroma (2005) 62: 441. doi:10.1365/s10337-005-0632-6
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The enantiomeric separation of 37 clinically used racemic basic drugs among 50 drugs was achieved using sulfated β-cyclodextrin (S-β-CD) as chiral selector at pH2.5 and in the reversed polarity mode. The results obtained in this study were different from the one obtained using neutral β-CD and its derivatives as chiral selectors. Using S-β-CD as chiral selector did not require the presence of the substructure 4H to achieve chiral separation as observed with β-Cyclodextrin (β-CD) and its derivatives since among the 37 separated drugs only 7 possess the 4H substructure. The chiral discrimination depends on the appropriate interaction between the analyte and the sulfated β-cyclodextrin.