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Oncoplastic Breast-Conserving Surgery for Tumors Larger than 2 Centimeters: Is it Oncologically Safe? A Matched-Cohort Analysis

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

An Erratum to this article was published on 22 February 2016

Abstract

Background

Oncoplastic surgery is a well-established approach that combines conserving treatment for breast cancer and plastic surgery techniques. Although this approach has been described for T2 tumors, no long-term oncologic follow-up and no comparison with patients undergoing mastectomy has been published. The purpose of the study was to demonstrate that oncoplastic surgery is a safe and reliable treatment for managing invasive primary T2 breast cancer.

Methods

We compared a consecutive series of 193 T2 patients who have undergone oncoplastic surgery (study group) with 386 T2 patients who have undergone mastectomy (control group). The endpoints evaluated were disease-free survival (DFS), overall survival (OS), cumulative incidence of local recurrence (CI-L), regional recurrence (CI-R), and distant recurrence (CI-D), all measured from the date of surgery.

Results

Median follow-up is 7.4 years. The OS is similar within the two groups: 87.3 and 87.1 % at 10 years in the ONC group and control group, respectively (p value, adjusted for multifocality and tumor size, 0.74). Also, the DFS is similar in both groups: 60.9 and 56.3 % at 10 years in the ONC group and control group, respectively. The incidence of local events is slightly higher in the oncoplastic group, whereas the incidence of regional events is slightly higher in the mastectomy group. These differences are not statistically significant. The cumulative incidence of distant events is similar within the two groups.

Conclusions

To our knowledge, the present study provides the best available evidence to suggest that oncoplastic approach is a safe and reliable treatment for managing invasive pT2 breast cancers.

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Disclosure

None of the authors has any commercial associations or financial interests to disclose. None of the authors received any funding for this work from any of the following organizations: National Institutes of Health (NIH); Wellcome Trust; Howard Hughes Medical Institute (HHMI); and other(s). Statement of Istitutional review board approval and/or statement of conforming to the declaration of Helsinky. This study is in compliance with the principles of the Helsinki Declaration.

Author information

Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, European Institute of Oncology, Milan, Italy

    Francesca De Lorenzi MD, PhD, Pietro Loschi MD, Gabriel Hubner MD & Rietjens Mario MD, PhD

  2. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

    Vincenzo Bagnardi PhD & Nicole Rotmensz MSc

  3. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy

    Vincenzo Bagnardi PhD

  4. Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy

    Giovanni Mazzarol MD

  5. Division of Radiotherapy, European Institute of Oncology, Milan, Italy

    Roberto Orecchia MD

  6. Department of Surgery, European Institute of Oncology, Milan, Italy

    Viviana Galimberti MD, Paolo Veronesi MD, Antonio Toesca MD & Nickolas Peradze MD

  7. Medical Senology, European Institute of Oncology, Milan, Italy

    Marco Angelo Colleoni MD

Authors
  1. Francesca De Lorenzi MD, PhD
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  2. Pietro Loschi MD
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  13. Rietjens Mario MD, PhD
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Corresponding author

Correspondence to Francesca De Lorenzi MD, PhD.

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De Lorenzi, F., Loschi, P., Bagnardi, V. et al. Oncoplastic Breast-Conserving Surgery for Tumors Larger than 2 Centimeters: Is it Oncologically Safe? A Matched-Cohort Analysis. Ann Surg Oncol 23, 1852–1859 (2016). https://doi.org/10.1245/s10434-016-5124-4

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  • DOI: https://doi.org/10.1245/s10434-016-5124-4

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