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Preoperative Chronic Kidney Disease Status is an Independent Prognostic Factor in Patients with Renal Cell Carcinoma

  • Urologic Oncology
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Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Preoperative chronic kidney disease (CKD) status may affect disease outcomes in patients with renal cell carcinoma (RCC). This study evaluated the influence of preoperative CKD status on clinicopathological features and prognosis in patients with RCC.

Methods

Between 1999 and 2011, a total of 1855 patients underwent radical nephrectomy at various centers throughout Korea. Of these patients, 1655 had an estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 (non-CKD group) and 200 patients had an eGFR ≥30 but <60 ml/min/1.73 m2 (CKD group). To reduce the effects of selection bias and potential confounding factors, 600 patients in the non-CKD group were selected by propensity-score matching.

Results

The median age of all patients was 57.3 years (range 20–94 years) and the median follow-up was 35.0 months (range 1–154 months). Comparisons of the propensity-score-matched cohorts showed that T and N stages were more advanced and tumor size was larger in the CKD group than in the non-CKD group (p < 0.05 each). Kaplan–Meier analyses showed that recurrence-free survival, cancer-specific survival (CSS), and overall survival (OS) were significantly lower in the CKD group (p < 0.01 each). Multivariate regression analysis showed that preoperative CKD status was an independent predictor of CSS and OS in patients with RCC (p < 0.05 each).

Conclusions

Preoperative CKD may be associated with more aggressive features and poorer prognosis in patients with RCC. RCC patients with preoperative CKD should be carefully and frequently followed-up after nephrectomy.

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Acknowledgment

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2011-0023308) and Ministry of Science, ICT and Future Planning (NRF-2014R1A2A1 A09006983).

Disclosure

Young-Won Kim, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim, Yun-Sok Ha, Yong Hyun Park, Seok Ho Kang, Sung-Hoo Hong, Tae Gyun Kwon, Seok-Soo Byun, Cheol Kwak, and Yong-June Kim declare that they have no conflicts of interest.

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Correspondence to Cheol Kwak MD, PhD or Yong-June Kim MD, PhD.

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Kim, YW., Kim, W.T., Yun, S.J. et al. Preoperative Chronic Kidney Disease Status is an Independent Prognostic Factor in Patients with Renal Cell Carcinoma. Ann Surg Oncol 22, 4098–4103 (2015). https://doi.org/10.1245/s10434-015-4444-0

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  • DOI: https://doi.org/10.1245/s10434-015-4444-0

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