Annals of Surgical Oncology

, Volume 19, Issue 3, pp 842–849

Comparison of Surgical Resection and Transarterial Chemoembolization for Hepatocellular Carcinoma beyond the Milan Criteria: A Propensity Score Analysis

  • Chia-Yang Hsu
  • Cheng-Yuan Hsia
  • Yi-Hsiang Huang
  • Chien-Wei Su
  • Han-Chieh Lin
  • Jih-Tung Pai
  • Che-Chuan Loong
  • Yi-You Chiou
  • Rheun-Chuan Lee
  • Fa-Yauh Lee
  • Teh-Ia Huo
  • Shou-Dong Lee
Hepatobiliary Tumors

DOI: 10.1245/s10434-011-2060-1

Cite this article as:
Hsu, CY., Hsia, CY., Huang, YH. et al. Ann Surg Oncol (2012) 19: 842. doi:10.1245/s10434-011-2060-1

Abstract

Background

Treatment for patients with intermediate-stage hepatocellular carcinoma (HCC) is controversial. This study compared the long-term survival of patients beyond the Milan criteria who received surgical resection (SR) or transarterial chemoembolization (TACE).

Methods

A total of 268 and 455 HCC patients beyond the Milan criteria undergoing SR and TACE, respectively, were retrospectively evaluated. After propensity score analysis to adjust for baseline differences, 146 pairs of matched patients were selected from each treatment arm. Long-term survival was compared by the Kaplan–Meier method. Independent prognostic predictors were determined by the Cox proportional hazards model.

Results

Long-term survival was significantly better for the SR group by univariate survival analysis (P < .001). In the Cox model, SR was identified as an independent predictor of better prognosis (hazard ratio = 0.3, 95% confidence interval [95% CI]: 0.23–0.4; P < .001). Despite similar baseline characteristics in the propensity score model, patients who underwent SR had significantly better survival than patients who underwent TACE (P < .001). Patients receiving TACE had 2.56-fold increased risk of long-term mortality in the propensity model (95% CI: 1.73–3.78). The SR and TACE groups had comparable 30- and 90-day posttreatment mortality. The Cox model consistently disclosed the significant superiority of SR in terms of long-term survival in the propensity score model (P < .001).

Conclusions

For HCC patients beyond the Milan criteria, SR is considered equally safe as TACE and provides better long-term survival. SR may be regarded as the priority treatment for these patients.

Copyright information

© Society of Surgical Oncology 2011

Authors and Affiliations

  • Chia-Yang Hsu
    • 1
    • 2
    • 3
  • Cheng-Yuan Hsia
    • 1
    • 4
  • Yi-Hsiang Huang
    • 2
    • 5
  • Chien-Wei Su
    • 1
    • 2
  • Han-Chieh Lin
    • 1
    • 2
  • Jih-Tung Pai
    • 1
    • 2
    • 3
  • Che-Chuan Loong
    • 1
    • 4
  • Yi-You Chiou
    • 1
    • 6
  • Rheun-Chuan Lee
    • 1
    • 6
  • Fa-Yauh Lee
    • 1
    • 2
  • Teh-Ia Huo
    • 2
    • 7
  • Shou-Dong Lee
    • 1
    • 2
  1. 1.Faculty of MedicineNational Yang-Ming University School of MedicineTaipeiTaiwan
  2. 2.Department of MedicineTaipei Veterans General HospitalTaipeiTaiwan
  3. 3.Department of MedicineNational Yang-Ming University HospitalYilanTaiwan
  4. 4.Department of SurgeryTaipei Veterans General HospitalTaipeiTaiwan
  5. 5.Institute of Clinical MedicineNational Yang-Ming University School of MedicineTaipeiTaiwan
  6. 6.Department of RadiologyTaipei Veterans General HospitalTaipeiTaiwan
  7. 7.Institute of PharmacologyNational Yang-Ming University School of MedicineTaipeiTaiwan