, Volume 17, Issue 7, pp 1721-1724
Date: 06 Apr 2010

7th Edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric Junction

This is an excerpt from the content

In previous editions of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, esophageal cancer staging was neither data driven nor harmonized with stomach cancer. The new staging system presented in the 7th edition of the AJCC Cancer Staging Manual, in contrast, is data driven and harmonized.1 This commentary describes development of the new system and highlights the changes and additions.

Data and Analysis

At the request of the AJCC, worldwide data were assembled to develop the 7th edition staging system for esophageal cancer.1 The Worldwide Esophageal Cancer Collaboration (WECC) was inaugurated in 2006. Thirteen institutions from five countries and three continents (Asia, Europe, and North America) submitted deidentified data by July 2007. These were used to construct a database of 4,627 esophagectomy patients who had no induction or adjuvant therapy to develop a staging system based on the pathologic tumor, node, metastasis (TNM) system.2

Several previously proposed rev