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Outcome Analysis of Patients with pN2 Oral Cavity Cancer

  • Head and Neck Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The American Joint Committee on Cancer staging system suggests that squamous-cell carcinoma of the oral cavity (OSCC) with pN2 should be classified as stage IVA. The objective of the current study was to determine the outcome of patients with pN2 OSCC cancer according to different T status.

Methods

Between January 1996 and September 2007, a total of 270 patients with pN2 OSCC cancer were analyzed. All participants had a follow-up of at least 2 years or were censored on the date of last follow-up. The outcome measures for this study were the 5-year rates of locoregional control, distant metastases, and survival.

Results

Five-year disease-specific survival and overall survival rates in pT1 (n = 9), pT2 (n = 98), pT3 (n = 70), and pT4 (n = 93) patients were 78%, 66%, 49%, 35% (P = 0.0031), and 78%, 52%, 35%, 23% (P = 0.0001), respectively. Multivariable analysis revealed that pT3–4, level IV/V metastases, extracapsular spread, and poor differentiation were independent risk factors for 5-year disease-specific survival in the entire study cohort. Specific independent prognostic factors for 5-year disease-specific survival according to T stage were found.

Conclusions

The results of this study suggest that patients with pN2 OSCC cancer have different outcomes and prognostic factors according to their T status. In the light of these findings, treatment strategies may be quite different.

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Acknowledgment

This study was supported by grants CMRPG370061 and CMRPG 370062 from the Chang Gung Memorial Hospital.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University at Linko, Taoyuan, Taiwan, ROC

    Chun-Ta Liao MD, Shiang-Fu Huang MD, I-How Chen MD & Chung-Jan Kang MD

  2. Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Chun-Ta Liao MD, Shiang-Fu Huang MD, I-How Chen MD, Chung-Jan Kang MD, Chien-Yu Lin MD, Kang-Hsing Fan MD, Hung-Ming Wang MD, Shu-Hang Ng MD, Chuen Hsueh MD, Li-Yu Lee MD, Chung-Kan Tsao MD & Tzu-Chen Yen MD, PhD

  3. Department of Radiation Oncology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University, Taoyuan, Taiwan, ROC

    Chien-Yu Lin MD & Kang-Hsing Fan MD

  4. Department of Hema-Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Hung-Ming Wang MD

  5. Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Shu-Hang Ng MD

  6. Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Chuen Hsueh MD & Li-Yu Lee MD

  7. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Chung-Kan Tsao MD

  8. Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, ROC

    Tzu-Chen Yen MD, PhD

  9. Department of Nuclear Medicine, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan, ROC

    Tzu-Chen Yen MD, PhD

Authors
  1. Chun-Ta Liao MD
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  2. Shiang-Fu Huang MD
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  3. I-How Chen MD
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  4. Chung-Jan Kang MD
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  5. Chien-Yu Lin MD
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  6. Kang-Hsing Fan MD
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  7. Hung-Ming Wang MD
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  8. Shu-Hang Ng MD
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  9. Chuen Hsueh MD
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  10. Li-Yu Lee MD
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  11. Chung-Kan Tsao MD
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  12. Tzu-Chen Yen MD, PhD
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Corresponding authors

Correspondence to Chun-Ta Liao MD or Tzu-Chen Yen MD, PhD.

Additional information

Chun-Ta Liao and Chung-Jan Kang contributed equally to this article, and both should be considered first author.

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Liao, CT., Huang, SF., Chen, IH. et al. Outcome Analysis of Patients with pN2 Oral Cavity Cancer. Ann Surg Oncol 17, 1118–1126 (2010). https://doi.org/10.1245/s10434-009-0894-6

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  • DOI: https://doi.org/10.1245/s10434-009-0894-6

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