Annals of Surgical Oncology

, Volume 24, Issue 3, pp 801–807

Long-Term Outcomes of 98 Surgically Resected Metastatic Tumors in the Pancreas

  • Shin-Rong Lee
  • Georgios Gemenetzis
  • Michol Cooper
  • Ammar A. Javed
  • John L. Cameron
  • Christopher L. Wolfgang
  • Frederick E. Eckhauser
  • Jin He
  • Matthew J. Weiss
Pancreatic Tumors

DOI: 10.1245/s10434-016-5619-z

Cite this article as:
Lee, SR., Gemenetzis, G., Cooper, M. et al. Ann Surg Oncol (2017) 24: 801. doi:10.1245/s10434-016-5619-z

Abstract

Purpose

The goal of this study was to assess the outcomes and characteristics of patients who underwent pancreatectomy for metastatic disease to the pancreas.

Methods

Patients who underwent surgical resection of metastatic disease to the pancreas from 1988 to 2016 were identified using a prospectively maintained database. Data on clinicopathological features and outcomes of these patients were analyzed. Cox proportional hazard models were employed to identify patient-specific risk factors that influence survival.

Results

Ninety-seven patients underwent 98 pancreatic metastasectomies from July 1988 through March 2016 for metastatic disease from 13 different primary cancers. Pancreaticoduodenectomy, distal pancreatectomy, and total pancreatectomy were performed in 49 (50 %), 37 (38 %), and 12 (12 %) patients, respectively. Postoperative complications occurred in 55 (56 %) patients, while 3 (3 %) perioperative deaths occurred. Median follow-up was 2.0 years, with a median survival of 3.2 years. Multivariate analysis revealed that older patients [hazard ratio (HR) 1.04/year; p = 0.006], non-renal cell carcinomas (HR 5.07; p < 0.001), vascular invasion (HR 3.53; p < 0.001), and positive resection margins (HR 2.62; p = 0.008) were independently associated with an increased risk of mortality.

Conclusions

Pancreatic metastasectomy is safe and feasible in well-selected patients and is associated with acceptable long-term survival.

Supplementary material

10434_2016_5619_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 14 kb)

Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Shin-Rong Lee
    • 1
  • Georgios Gemenetzis
    • 2
  • Michol Cooper
    • 2
  • Ammar A. Javed
    • 2
  • John L. Cameron
    • 2
  • Christopher L. Wolfgang
    • 2
  • Frederick E. Eckhauser
    • 2
  • Jin He
    • 2
  • Matthew J. Weiss
    • 2
  1. 1.Department of SurgeryYale University School of MedicineNew HavenUSA
  2. 2.Department of SurgeryJohns Hopkins University School of MedicineBaltimoreUSA

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