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Acute and Chronic Complications in Breast Cancer Patients Treated with Intraoperative Radiation Therapy

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Introduction

Intraoperative radiation therapy (IORT) permits the delivery of radiation therapy directly to the tumor bed at the time of surgery. Minimal data are available about the complications associated with this modality of treatment using the Xoft® Axxent Electronic Brachytherapy (Axxent) System.

Methods

A total of 702 patients who received IORT using the Xoft® Axxent System at Hoag Memorial Hospital Presbyterian between June 2010-February 2016 were accrued in an IORT data registry study. The prospective and retrospective protocols were approved by the institutional review board and met the guidelines of their responsible governmental agency. Data were collected at 1 week, 1 month, 3 months, 6 months, 1 year, and thereafter yearly. Acute complications were defined as those occurring within the first month. Chronic complications were those that persisted beyond 6 months.

Results

Acute complications were observed in 21 % of patients and included hematomas that required drainage, seromas requiring drainage more than 3 times, infections treated with antibiotics or surgery, necrosis requiring surgery, and erythema. Chronic complications were observed in 13 % of patients and included seromas, fibrosis, and hyperpigmentation. The majority of acute and chronic problems from IORT were mild. If grade I erythema, fibrosis, and hyperpigmentation were removed, only 32 of 702 (4.6 %) had significant complications. Our complication rates were comparable to those of the TARGIT trial.

Conclusions

IORT is a modality that safely delivers radiation therapy to patients diagnosed with breast cancer. This technique allows women who cannot (or decline to) undergo whole breast radiation to consider breast-conserving therapy rather than mastectomy.

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Authors and Affiliations

  1. Hoag Institute for Research and Education, Hoag Memorial Hospital Presbyterian, Newport Beach, USA

    Melinda Epstein PhD & Cristina De Leon RN, BSN

  2. Department of Surgery, Hoag Memorial Hospital Presbyterian, Newport Beach, USA

    Melvin Silverstein MD, Sadia Khan DO, Lincoln Snyder MD & Colleen Coleman MD

  3. Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, USA

    Melvin Silverstein MD & Sadia Khan DO

  4. Department of Radiology, Hoag Memorial Hospital Presbyterian, Newport Beach, USA

    Kevin Lin MD, Brian Kim MD, January Lopez MD, Ralph Mackintosh PhD & Peter Chen MD

  5. BreastLink, Orange, USA

    Lisa Guerra MD

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  1. Melinda Epstein PhD
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  2. Melvin Silverstein MD
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  7. Lisa Guerra MD
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Correspondence to Melinda Epstein PhD.

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Epstein, M., Silverstein, M., Lin, K. et al. Acute and Chronic Complications in Breast Cancer Patients Treated with Intraoperative Radiation Therapy. Ann Surg Oncol 23, 3304–3309 (2016). https://doi.org/10.1245/s10434-016-5316-y

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  • DOI: https://doi.org/10.1245/s10434-016-5316-y

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