Annals of Surgical Oncology

, Volume 24, Issue 3, pp 832–840

CXCR4 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

  • Masakazu Goto
  • Takahiro Yoshida
  • Yota Yamamoto
  • Yoshihito Furukita
  • Seiya Inoue
  • Satoshi Fujiwara
  • Naoya Kawakita
  • Takeshi Nishino
  • Takuya Minato
  • Yasuhiro Yuasa
  • Hiromichi Yamai
  • Hirokazu Takechi
  • Junichi Seike
  • Yoshimi Bando
  • Akira Tangoku
Translational Research and Biomarkers

DOI: 10.1245/s10434-015-4974-5

Cite this article as:
Goto, M., Yoshida, T., Yamamoto, Y. et al. Ann Surg Oncol (2017) 24: 832. doi:10.1245/s10434-015-4974-5

Abstract

Background

Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The chemokine CXCL12 and its receptors CXCR4 and CXCR7 were suggested to be involved in cancer invasion and metastasis. The aim of this retrospective study was to evaluate the prognostic impact of the expressions of CXCL12, CXCR4 and CXCR7 in patients with esophageal squamous cell carcinoma (ESCC).

Methods

We used immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate the expressions of CXCL12, CXCR4, and CXCR7 in ESCC patients’ tumor biopsy specimens obtained during preoperative endoscopy or surgery. These results were compared with the patients’ clinicopathological parameters and survival.

Results

IHC was conducted for 172 patients. High expression of CXCR4 in the cytoplasm and nuclei and that of CXCR7 were associated with poor cause-specific survival (CSS) (P= .002 and .010, respectively). The specimens from 52 of the 172 patients were examined by RT-PCR and quantitative real-time PCR. The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumors compared with normal esophageal mucosae (P < .0001). The expression level of mRNA of CXCR4 was associated with poor recurrence-free survival and CSS (P = .012 and .038, respectively).

Conclusions

CXCR4 expression is associated with poor prognosis in patients with ESCC.

Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Masakazu Goto
    • 1
  • Takahiro Yoshida
    • 1
  • Yota Yamamoto
    • 2
  • Yoshihito Furukita
    • 3
  • Seiya Inoue
    • 1
  • Satoshi Fujiwara
    • 3
  • Naoya Kawakita
    • 1
  • Takeshi Nishino
    • 1
  • Takuya Minato
    • 4
  • Yasuhiro Yuasa
    • 5
  • Hiromichi Yamai
    • 6
  • Hirokazu Takechi
    • 1
  • Junichi Seike
    • 1
  • Yoshimi Bando
    • 7
  • Akira Tangoku
    • 1
  1. 1.Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical SciencesTokushima University Graduate SchoolTokushimaJapan
  2. 2.Sainokuni Higashiomiya Medical CenterSaitamaJapan
  3. 3.Kochi Health Sciences CenterKochiJapan
  4. 4.Shikoku Medical Center for Children and AdultsKagawaJapan
  5. 5.Tokushima Red Cross HospitalTokushimaJapan
  6. 6.Kochi Red Cross HospitalKochiJapan
  7. 7.Department of Molecular and Environmental Pathology, Institute of Biomedical SciencesTokushima University Graduate SchoolTokushimaJapan

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