Annals of Surgical Oncology

, Volume 23, Issue 3, pp 1026–1033

Minimally Invasive Pancreaticoduodenectomy Does Not Improve Use or Time to Initiation of Adjuvant Chemotherapy for Patients With Pancreatic Adenocarcinoma

  • Daniel P. Nussbaum
  • Mohamed A. Adam
  • Linda M. Youngwirth
  • Asvin M. Ganapathi
  • Sanziana A. Roman
  • Douglas S. Tyler
  • Julie A. Sosa
  • Dan G. BlazerIII
Pancreatic Tumors

DOI: 10.1245/s10434-015-4937-x

Cite this article as:
Nussbaum, D.P., Adam, M.A., Youngwirth, L.M. et al. Ann Surg Oncol (2016) 23: 1026. doi:10.1245/s10434-015-4937-x

Abstract

Background

The modifiable variable best proven to improve survival after resection of pancreatic adenocarcinoma is the addition of adjuvant chemotherapy. A theoretical advantage of minimally invasive pancreaticoduodenectomy (MI-PD) is the potential for greater use and earlier initiation of adjuvant therapy, but this benefit remains unproven.

Methods

The 2010–2012 National Cancer Data Base (NCDB) was queried for patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma. Subjects were classified as MI-PD versus open pancreaticoduodenectomy (O-PD). Baseline variables were compared between groups. The independent effect of surgical approach on the use and timing of adjuvant chemotherapy was estimated using multivariable regression analyses.

Results

For this study, 7967 subjects were identified: 1191 MI-PD (14.9 %) and 6776 O-PD (85.1 %) patients. Patients who underwent MI-PD were more likely to have been treated at academic hospitals. Otherwise, the groups had no baseline differences. In both the MI-PD and O-PD groups, approximately 50 % of the patients received adjuvant chemotherapy, initiated at a median of 54 versus 55 days postoperatively (p = 0.08). After multivariable adjustment, surgical approach was not independently associated with use (odds ratio 1.00; p = 0.99) or time to initiation of adjuvant chemotherapy (–2.3 days; p = 0.07). Younger age, insured status, lower comorbidity score, higher tumor stage, and the presence of lymph node metastases were independently associated with the use of adjuvant chemotherapy.

Conclusions

At a national level, MI-PD does not result in greater use or earlier initiation of adjuvant chemotherapy. As surgeons and institutions continue to gain experience with this complex procedure, it will be important to revisit this benchmark as a justification for its increasing use for patients with pancreatic cancer.

Supplementary material

10434_2015_4937_MOESM1_ESM.docx (12 kb)
Supplementary material 1 (DOCX 12 kb)

Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Daniel P. Nussbaum
    • 1
  • Mohamed A. Adam
    • 1
  • Linda M. Youngwirth
    • 1
  • Asvin M. Ganapathi
    • 1
  • Sanziana A. Roman
    • 1
  • Douglas S. Tyler
    • 2
  • Julie A. Sosa
    • 1
  • Dan G. BlazerIII
    • 1
  1. 1.Department of SurgeryDuke UniversityDurhamUSA
  2. 2.Department of SurgeryThe University of Texas Medical BranchGalvestonUSA

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