Annals of Surgical Oncology

, Volume 21, Issue 2, pp 513–519

Perioperative Antimicrobial Prophylaxis for Intra-abdominal Surgery in Patients with Cancer: A Retrospective Study Comparing Ertapenem and Nonertapenem Antibiotics

Authors

  • Sminil N. Mahajan
    • Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460The University of Texas MD Anderson Cancer Center
  • Ella J. Ariza-Heredia
    • Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460The University of Texas MD Anderson Cancer Center
  • Kenneth V. Rolston
    • Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460The University of Texas MD Anderson Cancer Center
  • Linda S. Graviss
    • Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460The University of Texas MD Anderson Cancer Center
  • Barry W. Feig
    • Department of Surgical OncologyThe University of Texas MD Anderson Cancer Center
  • Thomas A. Aloia
    • Department of Surgical OncologyThe University of Texas MD Anderson Cancer Center
    • Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460The University of Texas MD Anderson Cancer Center
Colorectal Cancer

DOI: 10.1245/s10434-013-3294-x

Cite this article as:
Mahajan, S.N., Ariza-Heredia, E.J., Rolston, K.V. et al. Ann Surg Oncol (2014) 21: 513. doi:10.1245/s10434-013-3294-x

Abstract

Background

To evaluate the role of ertapenem versus other standard antibiotic prophylaxis in patients with cancer undergoing intra-abdominal surgery.

Methods

Our study was a retrospective cohort study consisting 615 patients who underwent intra-abdominal surgery at our institution between January 2007 and December 2010. The groups were divided among patients who received ertapenem as perioperative prophylaxis (ertapenem group) and patients who received other antibiotics (nonertapenem group). Groups were similar with respect to age, gender, and type of surgery.

Results

A total of 315 patients underwent colorectal and 300 noncolorectal surgeries. In a multivariate logistic regression model, the main factors associated with risk of surgical site infections (SSI) were as follows: antibiotics within 3 months of surgery (odds ratio [OR] 1.2, 95 % confidence interval [CI] 1.04–1.54; p = 0.05), prior hospitalization within 1 year (OR 1.21, 95 % CI 1.02–1.43; p = 0.05), diabetes mellitus (OR 2.1, 95 % CI 1.7–3.4; p = 0.04), and perioperative prophylaxis other than ertapenem (OR 1.7, 95 % CI 1.2–2.3; p = 0.04). Notably, patients who underwent colorectal surgery and received ertapenem had a lower rate of SSI (4 % ertapenem vs. 13 % nonertapenem, p = 0.01), whereas the frequency of infections was not different in patients who underwent other intra-abdominal surgery whether they received ertapenem or not.

Conclusions

The use of ertapenem for perioperative prophylaxis in patients with colorectal surgery was associated with lower rates of SSI, while there was no difference in rates of infection in other intra-abdominal surgery.

Copyright information

© Society of Surgical Oncology 2013