Annals of Surgical Oncology

, Volume 21, Issue 5, pp 1501–1505

Consensus Guidelines from The American Society of Peritoneal Surface Malignancies on Standardizing the Delivery of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Patients in the United States


  • K. Turaga
    • Medical College of Wisconsin
  • E. Levine
    • Wake Forest University Baptist Medical Center
  • R. Barone
    • Sharp Health Care
  • R. Sticca
    • University of North Dakota
  • N. Petrelli
    • Christiana Care Health System
  • L. Lambert
    • UMass Memorial Medical Center
  • G. Nash
    • Memorial Sloan-Kettering Cancer Center
  • M. Morse
    • Duke University
  • R. Adbel-Misih
    • Christiana Care Health System
  • H. R. Alexander
    • University of Maryland Medical Center
  • F. Attiyeh
    • St. Luke’s-Roosevelt Hospital Center
  • D. Bartlett
    • University of Pittsburgh
  • A. Bastidas
    • National Surgical Associates
  • T. Blazer
    • Duke University
  • Q. Chu
    • Louisiana State University Health Sciences Center
  • K. Chung
    • Memorial Sloan-Kettering Cancer Center
  • L. Dominguez-Parra
    • Hospital Regional De Alta Especialidad De La Yucatan
  • N. J. Espat
    • Roger Williams Medical Center
  • J. Foster
    • University of Nebraska Medical Center
  • K. Fournier
    • MD Anderson Cancer Center
  • R. Garcia
    • Hospital Regional De Alta Especialidad De Oaxaca
  • M. Goodman
    • Tuff’s Medical Center
  • N. Hanna
    • University of Maryland Medical Center
  • L. Harrison
    • New Jersey Medical School
  • R. Hoefer
    • Sentara Surgical Associates
  • M. Holtzman
    • University of Pittsburgh
  • J. Kane
    • Roswell Park Cancer Center
  • D. Labow
    • Mount Sinai Medical Center
  • B. Li
    • Louisiana State University Health Sciences Center
  • A. Lowy
    • San Diego Medical Center, University of California
  • P. Mansfield
    • MD Anderson Cancer Center
  • E. Ong
    • University of Arizona
  • C. Pameijer
    • Stony Brook University Medical Center
  • J. Pingpank
    • UPMC Cancer Pavilion
  • M. Quinones
    • Dekalb Medical Center
  • R. Royal
    • MD Anderson Cancer Center
  • G. Salti
    • University of Illinois Masonic Medical Center
  • A. Sardi
    • Mercy Medical Center
  • P. Shen
    • Wake Forest University Baptist Medical Center
  • J. Skitzki
    • Roswell Park Cancer Center
  • J. Spellman
    • Beebe Medical Center
  • J. Stewart
    • Wake Forest University Baptist Medical Center
    • St. Agnes Hospital
Gastrointestinal Oncology

DOI: 10.1245/s10434-013-3061-z

Cite this article as:
Turaga, K., Levine, E., Barone, R. et al. Ann Surg Oncol (2014) 21: 1501. doi:10.1245/s10434-013-3061-z



The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC.


A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests.


Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin.


This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

Copyright information

© Society of Surgical Oncology 2013