Annals of Surgical Oncology

, Volume 21, Issue 5, pp 1501–1505

Consensus Guidelines from The American Society of Peritoneal Surface Malignancies on Standardizing the Delivery of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Patients in the United States

  • K. Turaga
  • E. Levine
  • R. Barone
  • R. Sticca
  • N. Petrelli
  • L. Lambert
  • G. Nash
  • M. Morse
  • R. Adbel-Misih
  • H. R. Alexander
  • F. Attiyeh
  • D. Bartlett
  • A. Bastidas
  • T. Blazer
  • Q. Chu
  • K. Chung
  • L. Dominguez-Parra
  • N. J. Espat
  • J. Foster
  • K. Fournier
  • R. Garcia
  • M. Goodman
  • N. Hanna
  • L. Harrison
  • R. Hoefer
  • M. Holtzman
  • J. Kane
  • D. Labow
  • B. Li
  • A. Lowy
  • P. Mansfield
  • E. Ong
  • C. Pameijer
  • J. Pingpank
  • M. Quinones
  • R. Royal
  • G. Salti
  • A. Sardi
  • P. Shen
  • J. Skitzki
  • J. Spellman
  • J. Stewart
  • J. Esquivel
Gastrointestinal Oncology

DOI: 10.1245/s10434-013-3061-z

Cite this article as:
Turaga, K., Levine, E., Barone, R. et al. Ann Surg Oncol (2014) 21: 1501. doi:10.1245/s10434-013-3061-z

Abstract

Background

The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC.

Methods

A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests.

Results

Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin.

Conclusions

This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • K. Turaga
    • 1
  • E. Levine
    • 2
  • R. Barone
    • 3
  • R. Sticca
    • 4
  • N. Petrelli
    • 5
  • L. Lambert
    • 6
  • G. Nash
    • 7
  • M. Morse
    • 8
  • R. Adbel-Misih
    • 5
  • H. R. Alexander
    • 9
  • F. Attiyeh
    • 10
  • D. Bartlett
    • 11
  • A. Bastidas
    • 12
  • T. Blazer
    • 8
  • Q. Chu
    • 13
  • K. Chung
    • 7
  • L. Dominguez-Parra
    • 14
  • N. J. Espat
    • 15
  • J. Foster
    • 16
  • K. Fournier
    • 17
  • R. Garcia
    • 18
  • M. Goodman
    • 19
  • N. Hanna
    • 9
  • L. Harrison
    • 20
  • R. Hoefer
    • 21
  • M. Holtzman
    • 11
  • J. Kane
    • 22
  • D. Labow
    • 23
  • B. Li
    • 13
  • A. Lowy
    • 24
  • P. Mansfield
    • 17
  • E. Ong
    • 25
  • C. Pameijer
    • 26
  • J. Pingpank
    • 27
  • M. Quinones
    • 28
  • R. Royal
    • 17
  • G. Salti
    • 29
  • A. Sardi
    • 30
  • P. Shen
    • 2
  • J. Skitzki
    • 22
  • J. Spellman
    • 31
  • J. Stewart
    • 2
  • J. Esquivel
    • 32
  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Wake Forest University Baptist Medical CenterWinston-SalemUSA
  3. 3.Sharp Health CareSan DiegoUSA
  4. 4.University of North DakotaGrand ForksUSA
  5. 5.Christiana Care Health SystemWilmingtonUSA
  6. 6.UMass Memorial Medical CenterWorcesterUSA
  7. 7.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  8. 8.Duke UniversityDurhamUSA
  9. 9.University of Maryland Medical CenterBaltimoreUSA
  10. 10.St. Luke’s-Roosevelt Hospital CenterNew YorkUSA
  11. 11.University of PittsburghPittsburghUSA
  12. 12.National Surgical AssociatesLos GatosUSA
  13. 13.Louisiana State University Health Sciences CenterNew OrleansUSA
  14. 14.Hospital Regional De Alta Especialidad De La YucatanMeridaMexico
  15. 15.Roger Williams Medical CenterProvidenceUSA
  16. 16.University of Nebraska Medical CenterOmahaUSA
  17. 17.MD Anderson Cancer CenterHoustonUSA
  18. 18.Hospital Regional De Alta Especialidad De OaxacaOaxacaCountry
  19. 19.Tuff’s Medical CenterBostonUSA
  20. 20.New Jersey Medical SchoolNewarkUSA
  21. 21.Sentara Surgical AssociatesChesapeakeUSA
  22. 22.Roswell Park Cancer CenterBuffaloUSA
  23. 23.Mount Sinai Medical CenterNew YorkUSA
  24. 24.San Diego Medical Center, University of CaliforniaSan DiegoUSA
  25. 25.University of ArizonaTucsonUSA
  26. 26.Stony Brook University Medical CenterStony BrookUSA
  27. 27.UPMC Cancer PavilionPittsburghUSA
  28. 28.Dekalb Medical CenterLithoniaUSA
  29. 29.University of Illinois Masonic Medical CenterChicagoUSA
  30. 30.Mercy Medical CenterBaltimoreUSA
  31. 31.Beebe Medical CenterLewesUSA
  32. 32.St. Agnes HospitalBaltimoreUSA