Annals of Surgical Oncology

, Volume 20, Issue 8, pp 2615–2624

Application of the Adjuvant! Online Model to Korean Breast Cancer Patients: An Assessment of Prognostic Accuracy and Development of an Alternative Prognostic Tool

Authors

  • Minkyu Jung
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
    • Cancer Metastasis Research CenterYonsei University College of Medicine
  • Eun Hee Choi
    • Department of BiostatisticsYonsei University College of Medicine
  • Chung Mo Nam
    • Department of BiostatisticsYonsei University College of Medicine
  • Sun Young Rha
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
    • Cancer Metastasis Research CenterYonsei University College of Medicine
    • BK2 1 Project for Medical ScienceYonsei University College of Medicine
  • Hei Cheul Jeung
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
    • Cancer Metastasis Research CenterYonsei University College of Medicine
  • Soo Hyun Lee
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
  • Woo Ick Yang
    • Department of PathologyYonsei University College of Medicine
    • BK2 1 Project for Medical ScienceYonsei University College of Medicine
  • Jae Kyung Roh
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
    • Cancer Metastasis Research CenterYonsei University College of Medicine
    • BK2 1 Project for Medical ScienceYonsei University College of Medicine
    • Division of Medical Oncology, Department of Internal MedicineYonsei University College of Medicine
    • Yonsei Cancer CenterYonsei University College of Medicine
    • Cancer Metastasis Research CenterYonsei University College of Medicine
    • BK2 1 Project for Medical ScienceYonsei University College of Medicine
Breast Oncology

DOI: 10.1245/s10434-013-2956-z

Cite this article as:
Jung, M., Choi, E.H., Nam, C.M. et al. Ann Surg Oncol (2013) 20: 2615. doi:10.1245/s10434-013-2956-z

Abstract

Background

Adjuvant! Online (AOL) is a Web-accessible risk-assessment model that predicts the mortality and the benefits of adjuvant therapy for breast cancer.

Methods

Using the Yonsei Tumor Registry database, patients with T1–3, N0–3, M0 breast cancer who were treated at the Yonsei Cancer Center between 1986 and 1999 were entered into AOL version 8.0 to calculate survival.

Results

The median age of the study population was 45 years (range, 23–76 years) and the median follow-up duration was 10.8 years (range, 0.1–25.9 years) for all 699 patients. AOL significantly overestimated overall survival (OS) (by 11.1 %, P < 0.001), breast cancer-specific survival (BCSS) (by 11.6 %, P < 0.001), and event free-free survival (EFS) (by 9.25 %, P < 0.001) in Korean patients. Therefore, we developed a Korean version of AOL (KAOL), which is a new model for prognosis based on AOL’s parameters. The observed 10-year OS (61.4 %), BCSS (62.3 %), and EFS (59.1 %) and the KAOL predicted OS (61.5 %), BCSS (63.5 %) and EFS (57.6 %) were not different (P = 0.976, P = 0.771, and P = 0.674, respectively).

Conclusions

AOL was not found to be suitable in Korean patients with breast cancer. The newly developed KAOL accurately predicted 10-year outcomes in Korean breast cancer patients.

Supplementary material

10434_2013_2956_MOESM1_ESM.doc (44 kb)
Supplementary material 1 (DOC 44 kb)

Copyright information

© Society of Surgical Oncology 2013