Annals of Surgical Oncology

, Volume 20, Issue 6, pp 1865–1871

Prognostic Value of Disseminated Tumor Cells in the Bone Marrow of Patients with Operable Primary Breast Cancer: A Long-term Follow-up Study

  • Christoph Domschke
  • Ingo J. Diel
  • Stefan Englert
  • Silvia Kalteisen
  • Luisa Mayer
  • Joachim Rom
  • Joerg Heil
  • Christof Sohn
  • Florian Schuetz
Breast Oncology

DOI: 10.1245/s10434-012-2814-4

Cite this article as:
Domschke, C., Diel, I.J., Englert, S. et al. Ann Surg Oncol (2013) 20: 1865. doi:10.1245/s10434-012-2814-4

Abstract

Background

Detection of disseminated tumor cells (DTC) in primary breast cancer (BC) patients’ bone marrow (BM) seems to be a surrogate marker of tumor spread and an independent prognostic factor for disease-free and overall survival.

Methods

Here we present the largest single-center cohort of patients (n = 1378) with the longest observation time (median 82.0 months). Immunocytochemical staining was performed using murine monoclonal antibody 2E11 with the avidin–biotin complex technique.

Results

At primary surgery, 49 % of patients showed MUC-1 positive cells inside their BM. Patients without BM DTC had significantly more often T1-tumors (P = 0.007) with less often affected axillary lymph nodes (P < 0.001). We observed a significantly higher incidence of distant metastases in DTC positive patients (P < 0.001). This leads to a reduced disease-free survival (P < 0.0001). Furthermore, in DTC positive patients there was a higher mortality rate and, accordingly, a reduced overall survival (P < 0.0001).

Conclusions

Due to the presence of BM DTC, patients with a clinically poorer outcome can be identified at primary surgery. We therefore suggest that DTC analysis can be used as a prognostic factor and monitoring tool in clinical trials. Future study concepts relating to DTC should aim at identification of BC patients who may profit from adjuvant systemic therapy.

Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Christoph Domschke
    • 1
  • Ingo J. Diel
    • 2
  • Stefan Englert
    • 3
  • Silvia Kalteisen
    • 1
  • Luisa Mayer
    • 1
  • Joachim Rom
    • 1
  • Joerg Heil
    • 1
  • Christof Sohn
    • 1
  • Florian Schuetz
    • 1
  1. 1.Breast UnitUniversity of HeidelbergHeidelbergGermany
  2. 2.CGG-Clinic MannheimMannheimGermany
  3. 3.Institute of Medical Biometry and Informatics, University of HeidelbergHeidelbergGermany