Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women
- Robert H. I. Andtbacka MD, CM,
- Matthew R. Donaldson MD,
- Tawnya L. Bowles MD,
- Glen M. Bowen MD,
- Kenneth Grossmann MD, PhD,
- Hung Khong MD,
- Douglas Grossman MD, PhD,
- Christopher Anker MD,
- Scott R. Florell MD,
- Anneli Bowen MD,
- Keith L. Duffy MD,
- Sancy A. Leachman MD, PhD,
- R. Dirk Noyes MD
- … show all 13 hide
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The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women.
A prospective melanoma database was retrospectively queried for women diagnosed with melanoma during or immediately before pregnancy as well as SLNB in pregnant women. The outcomes of SLNB for the mothers and fetuses were evaluated.
Fifteen pregnant women underwent wide local excision (WLE) and SLNB for melanoma from 1997 to 2012. The median gestational age was 20 weeks. More than half of the women noticed changes in the primary melanoma lesion during the pregnancy. The median Breslow thickness was 1.00 mm. Lymphatic mapping and SLNB were performed with some combination of radiocolloid or vital blue dye without adverse effects. Three patients had micrometastatic disease and underwent a completion lymphadenectomy. Sixteen children were born at a median gestational age of 39 weeks. The median 1- and 5-minute Apgar scores were 8 and 9, respectively. At a median follow-up of 54.4, months none of the patients had experienced recurrence, and all children were healthy and free of melanoma.
In this series of pregnant women with melanoma, SLNB was performed safely during pregnancy without adverse effects to the mothers and fetuses. We recommend that clinicians explain the risks and benefits of the SLNB procedure to pregnant women so an informed decision can be made about the procedure.
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- Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women
Annals of Surgical Oncology
Volume 20, Issue 2 , pp 689-696
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- Online ISSN
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- Robert H. I. Andtbacka MD, CM (1)
- Matthew R. Donaldson MD (1) (2)
- Tawnya L. Bowles MD (1)
- Glen M. Bowen MD (1)
- Kenneth Grossmann MD, PhD (1)
- Hung Khong MD (1)
- Douglas Grossman MD, PhD (1)
- Christopher Anker MD (1)
- Scott R. Florell MD (1)
- Anneli Bowen MD (1)
- Keith L. Duffy MD (1)
- Sancy A. Leachman MD, PhD (1)
- R. Dirk Noyes MD (1)
- Author Affiliations
- 1. Melanoma and Cutaneous Oncology Program, Huntsman Cancer Institute, University of Utah and Intermountain Health Care, Salt Lake City, UT, USA
- 2. Mount West Dermatology, P.C., Grand Junction, CO, USA