Annals of Surgical Oncology

, Volume 19, Issue 10, pp 3131–3138

Long-Term Follow-up of Lobular Neoplasia (Atypical Lobular Hyperplasia/Lobular Carcinoma In Situ) Diagnosed on Core Needle Biopsy

  • Miraj G. Shah-Khan
  • Xochiquetzal J. Geiger
  • Carol Reynolds
  • James W. Jakub
  • Elizabeth R. DePeri
  • Katrina N. Glazebrook
Breast Oncology

DOI: 10.1245/s10434-012-2534-9

Cite this article as:
Shah-Khan, M.G., Geiger, X.J., Reynolds, C. et al. Ann Surg Oncol (2012) 19: 3131. doi:10.1245/s10434-012-2534-9

Abstract

Background

Lobular neoplasia (LN) includes atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). LN often is an incidental finding on breast core needle biopsy (CNBx) and management remains controversial. Our objective was to define the incidence of malignancy in women diagnosed with pure LN on CNBx, and identify a subset of patients that may be observed.

Methods

Patients diagnosed with LN on CNB between January 1993 and December 2010 were identified. Patients with an associated high-risk lesion or ipsilateral malignancy at time of diagnosis were excluded. All cases were reviewed by dedicated breast pathologists and breast imagers for pathologic classification and radiologic concordance, respectively.

Results

The study cohort was comprised of 184 (1.3 %) cases of pure LN (147 ALH, 37 LCIS) from 180 patients. Pathologic–radiologic concordance was achieved in 171 (93 %) cases. Excision was performed in 101 (55 %) cases and 83 (45 %) were observed. Mean follow-up was 50.3 (range, 6–212) months. Of cases excised, 1 of 81 (1.2 %) ALH and 1 of 20 (5 %) LCIS cases were upstaged to ductal carcinoma in situ (DCIS) and invasive lobular carcinoma (ILC), respectively. Only 1 of 101 (1 %) concordant lesions was upstaged on excision. Of the cases observed, 4 of 65 (6.2 %) developed ipsilateral cancer during follow-up: 1 of 51 (2 %) case of ALH and 3 of 14 (21.4 %) cases with LCIS (2 ILC, 2 DCIS). During follow-up, 2.9 % (4/138) patients with excised or observed LN developed a contralateral cancer.

Conclusions

These data support that not all patients with LN diagnosed on CNB require surgical excision. Patients with pure ALH, demonstrating radiologic–pathologic concordance, may be safely observed.

Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Miraj G. Shah-Khan
    • 1
  • Xochiquetzal J. Geiger
    • 2
  • Carol Reynolds
    • 3
  • James W. Jakub
    • 1
  • Elizabeth R. DePeri
    • 4
  • Katrina N. Glazebrook
    • 5
  1. 1.Department of SurgeryMayo ClinicRochesterUSA
  2. 2.Department of Laboratory MedicineMayo ClinicJacksonvilleUSA
  3. 3.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  4. 4.Department of RadiologyMayo ClinicJacksonvilleUSA
  5. 5.Department of RadiologyMayo ClinicRochesterUSA