Annals of Surgical Oncology

, Volume 19, Issue 6, pp 2003–2010

The Determining Risk Factors for Treatment Outcomes in Patients with Squamous Cell Carcinoma of the Hard Palate

  • Fan-Yu Meng
  • Jeng-Yuh Ko
  • Pei-Jen Lou
  • Cheng-Ping Wang
  • Tsung-Lin Yang
  • Chun-Hsiang Chang
  • Yih-Leong Chang
  • Tseng-Cheng Chen
Head and Neck Oncology

DOI: 10.1245/s10434-011-2214-1

Cite this article as:
Meng, FY., Ko, JY., Lou, PJ. et al. Ann Surg Oncol (2012) 19: 2003. doi:10.1245/s10434-011-2214-1

Abstract

Background

The determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified.

Methods

Medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between March 2003 and May 2009 were reviewed.

Results

Seventy-eight patients were enrolled in the study. The 5 year disease-free and overall survival rates were 49.8 and 49.7%, respectively. The 5 year disease-free and overall survival rates were statistically different between positive/close margins and negative margins (24.6% vs. 65.4%, P = 0.02; 20.1% vs. 63.1%, P = 0.001, respectively), with and without soft palate invasion (38.8% vs. 68.9%, P = 0.02; 27.4% vs. 77.5%, P = 0.001, respectively), and soft palate invasion patients with and without perineural invasion (10.4% vs. 52.8%, P = 0.02; 0% vs. 38.1%, P = 0.008, respectively). The rate of positive nodal metastasis for T3 and T4 tumors was 44%. For the tumor with soft palate invasion, the rate of positive nodal metastasis was 29%. After multivariate analyses, soft palate invasion and positive/close margins were the determining risk factors for disease-free and overall survival.

Conclusions

Soft palate invasion and positive/close margins were the determining risk factors for disease-free and overall survival in patients with squamous cell carcinoma of the hard palate. Elective neck dissection is suggested for advanced primary tumors (T3 or T4) or tumors with soft palate invasion.

Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Fan-Yu Meng
    • 1
  • Jeng-Yuh Ko
    • 1
  • Pei-Jen Lou
    • 1
  • Cheng-Ping Wang
    • 1
    • 2
  • Tsung-Lin Yang
    • 1
  • Chun-Hsiang Chang
    • 3
    • 4
  • Yih-Leong Chang
    • 5
    • 6
  • Tseng-Cheng Chen
    • 1
    • 6
    • 7
  1. 1.Department of OtolaryngologyNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  2. 2.Institute of Biomedical Engineering, College of Medicine and College of EngineeringNational Taiwan UniversityTaipeiTaiwan
  3. 3.Department of OtolaryngologyCatholic Cardinal Tien Hospital, Fu-Jen Catholic University College of MedicineTaipeiTaiwan
  4. 4.Institute of Epidemiology and Preventive Medicine, College of Public HealthNational Taiwan UniversityTaipeiTaiwan
  5. 5.Department of PathologyNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  6. 6.Graduate Institute of Pathology, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  7. 7.Department of OtolaryngologyNational Taiwan University Hospital Yun-Lin BranchHuweiTaiwan