Head and Neck Oncology

Annals of Surgical Oncology

, Volume 19, Issue 6, pp 1995-2002

First online:

Treatment for T1-2 Oral Squamous Cell Carcinoma with or Without Perineural Invasion: Neck Dissection and Postoperative Adjuvant Therapy

  • Shyh-Kuan TaiAffiliated withDepartment of Otolaryngology, National Yang-Ming UniversityDepartment of Otolaryngology, Taipei Veterans General HospitalInstitute of Clinical Medicine, National Yang-Ming University Email author 
  • , Wing-Yin LiAffiliated withDepartment of Pathology, Taipei Veterans General Hospital
  • , Muh-Hwa YangAffiliated withDepartment of Otolaryngology, Taipei Veterans General HospitalDivision of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital
  • , Shyue-Yih ChangAffiliated withDepartment of Otolaryngology, National Yang-Ming UniversityDepartment of Otolaryngology, Taipei Veterans General Hospital
  • , Pen-Yuan ChuAffiliated withDepartment of Otolaryngology, Taipei Veterans General Hospital
  • , Tung-Lung TsaiAffiliated withDepartment of Otolaryngology, Taipei Veterans General Hospital
  • , Yi-Fen WangAffiliated withDepartment of Otolaryngology, Taipei Veterans General Hospital
  • , Peter Mu-Hsin ChangAffiliated withDepartment of Otolaryngology, Taipei Veterans General HospitalDivision of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital

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Abstract

Background

Although perineural invasion (PNI) has been a poor prognostic factor for head and neck cancers, few studies have focused on oral squamous cell carcinoma (OSCC). The independent significance of PNI in early T1-2 OSCC and the benefit of treatment modification based on PNI status have not been assessed. This study investigated the role of PNI in T1-2 OSCC patients, with focus on the controversial issues of neck management and postoperative adjuvant therapy.

Methods

PNI status was re-reviewed under hematoxylin and eosin staining in tumors of 307 consecutive T1-2 OSCC patients. Oncologic and survival outcomes were analyzed by univariate and multivariate analyses.

Results

PNI was identified in 84 (27.4%) patients, correlating with several established poor prognostic factors. In multivariate analysis, PNI remained an independent predictor for neck metastasis, neck recurrence, and a worse 5-year disease-specific survival. Elective neck dissection contributed to a significantly better 5-year disease-specific survival only in cN0 patients with PNI-positive tumors (P = 0.0071) but not in those with PNI-negative tumors (P = 0.3566). In low-risk patients who were treated by surgery alone, including neck dissection, the 5-year disease-specific survival rates were almost the same in those with PNI-positive tumors and those with PNI-negative tumors (92.0 vs. 92.9%; P = 0.9104).

Conclusions

Elective neck dissection is indicated for cN0 patients with PNI-positive tumors for the efficacy of improving disease-specific survival as well as neck control. However, low-risk PNI-positive patients who undergo neck dissection do not need postoperative adjuvant therapy, because the residual risk from PNI is minimal.