Annals of Surgical Oncology

, Volume 18, Issue 13, pp 3593–3600

Factors Predictive of the Status of Sentinel Lymph Nodes in Melanoma Patients from a Large Multicenter Database

Authors

    • Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer CenterCarolinas Medical Center
  • Gregory D. Ayers
    • Vanderbilt University School of Medicine
  • Virginia H. Stell
    • Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer CenterCarolinas Medical Center
  • Shouluan Ding
    • University of Alabama at Birmingham
  • Jeffrey E. Gershenwald
    • University of Texas M. D. Anderson Cancer Center
  • Jonathan C. Salo
    • Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer CenterCarolinas Medical Center
  • Barbara A. Pockaj
    • Mayo Clinic
  • Richard Essner
    • John Wayne Cancer Institute
  • Mark Faries
    • John Wayne Cancer Institute
  • Kim James Charney
    • St. Joseph Hospital
  • Eli Avisar
    • Miller School of MedicineUniversity of Miami
  • Axel Hauschild
    • University of Kiel
  • Friederike Egberts
    • University of Kiel
  • Bruce J. Averbook
    • MetroHealth Medical Center
  • Carlos A. Garberoglio
    • Loma Linda University Medical Center
  • John T. Vetto
    • Oregon Health & Science University
  • Merrick I. Ross
    • University of Texas M. D. Anderson Cancer Center
  • David Chu
    • City of Hope Medical Center
  • Vijay Trisal
    • City of Hope Medical Center
  • Harald Hoekstra
    • Groningen University Medical Center
  • Eric Whitman
    • Atlantic Melanoma CenterAtlantic Health
  • Harold J. Wanebo
    • Roger Williams Medical Center
  • Daniel DeBonis
    • University of Buenos Aires
  • Michael Vezeridis
    • Rhode Island Hospital
  • Aaron Chevinsky
    • Morristown Memorial Hospital
  • Mohammed Kashani-Sabet
    • California Pacific Medical Center and Research Institute
  • Yu Shyr
    • Vanderbilt University School of Medicine
  • Lynne Berry
    • Vanderbilt University School of Medicine
  • Zhiguo Zhao
    • Vanderbilt University School of Medicine
  • Seng-jaw Soong
    • University of Alabama at Birmingham
  • Stanley P. L. Leong
    • California Pacific Medical Center and Research Institute
  • for the Sentinel Lymph Node Working Group
Melanomas

DOI: 10.1245/s10434-011-1826-9

Cite this article as:
White, R.L., Ayers, G.D., Stell, V.H. et al. Ann Surg Oncol (2011) 18: 3593. doi:10.1245/s10434-011-1826-9

Abstract

Background

Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database.

Methods

Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed.

Results

Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN.

Conclusions

These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.

Copyright information

© Society of Surgical Oncology 2011