Pancreatic Tumors

Annals of Surgical Oncology

, Volume 17, Issue 8, pp 2092-2101

First online:

Unresectable Locally Advanced Pancreatic Cancer: A Multimodal Treatment Using Neoadjuvant Chemoradiotherapy (Gemcitabine Plus Stereotactic Radiosurgery) and Subsequent Surgical Exploration

  • Francesco PolistinaAffiliated withDepartment of Surgery, San Bortolo HospitalDepartment of Medical and Surgical Emergencies, Dolo Hospital Email author 
  • , Giorgio CostantinAffiliated withDepartment of Surgery, San Bortolo Hospital
  • , Franco CasamassimaAffiliated withClinical Radiological Institute, University of Florence
  • , Paolo FrancesconAffiliated withService of Medicine Applied Physics, San Bortolo Hospital
  • , Rosabianca GuglielmiAffiliated withSection of Radiotherapy, San Bortolo Hospital
  • , Gino PanizzoniAffiliated withSection of Radiotherapy, San Bortolo Hospital
  • , Antonio FebbraroAffiliated withDepartment of Oncology, Fatebenefratelli Hospital
  • , Giovanni AmbrosinoAffiliated withSchool of General Surgery, University of Padua

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Pancreatic cancer accounts for approximately 3% of cancer deaths in Europe. Locally advanced pancreatic cancer (LAPC) involves vascular structures, and resectability is low, with a median survival time of 6 to 11 months. We conducted a prospective, nonrandomized study of patients with LAPC to assess the effect of stereotactic body radiotherapy (SBRT) on local response, pain control, and quality of life (QOL).


Twenty-three patients with histologically confirmed LAPC underwent SBRT. Radiotherapy (30 Gy) was delivered in three fractions, and treatment toxicity was assessed according to the Common Terminology Criteria for Adverse Events (CTCAE v. 3.0). All patients received also gemcitabine chemotherapy and were followed up until death. Local control was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria, pain control was assessed with a visual analog scale, and QOL was assessed with the SF-36 instrument (Italian v. 1.6).


No grade 2 or higher acute or late toxicity was observed. The overall local response ratio was 82.6% (14 partial response, 2 complete response, 3 stable disease). SBRT showed a good short-term efficacy in controlling both pain and QOL. Median survival was 10.6 months, with a median follow-up of 9 months. The LAPC became resectable in 8% of the patients. Median time to progression of disease was 7.3 months. Six patients developed early metastatic disease.


The SBRT method is a promising treatment for LAPC. Local control rates, even compared to historical data from conventional radiotherapy, can be achieved with minimal toxicity. Resectability can also be achieved.