Annals of Surgical Oncology

, Volume 17, Issue 4, pp 1118–1126

Outcome Analysis of Patients with pN2 Oral Cavity Cancer

Authors

    • Department of Otorhinolaryngology, Head and Neck SurgeryChang Gung Memorial Hospital and Chang Gung University at Linko
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
  • Shiang-Fu Huang
    • Department of Otorhinolaryngology, Head and Neck SurgeryChang Gung Memorial Hospital and Chang Gung University at Linko
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
  • I-How Chen
    • Department of Otorhinolaryngology, Head and Neck SurgeryChang Gung Memorial Hospital and Chang Gung University at Linko
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
  • Chung-Jan Kang
    • Department of Otorhinolaryngology, Head and Neck SurgeryChang Gung Memorial Hospital and Chang Gung University at Linko
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
  • Chien-Yu Lin
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of Radiation OncologyChang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University
  • Kang-Hsing Fan
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of Radiation OncologyChang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University
  • Hung-Ming Wang
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of Hema-OncologyChang Gung Memorial Hospital and Chang Gung University
  • Shu-Hang Ng
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of Diagnostic RadiologyChang Gung Memorial Hospital and Chang Gung University
  • Chuen Hsueh
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of PathologyChang Gung Memorial Hospital and Chang Gung University
  • Li-Yu Lee
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of PathologyChang Gung Memorial Hospital and Chang Gung University
  • Chung-Kan Tsao
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Department of Plastic and Reconstructive SurgeryChang Gung Memorial Hospital and Chang Gung University
    • Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung University
    • Nuclear Medicine and Molecular Imaging CenterChang Gung Memorial Hospital and Chang Gung University
    • Department of Nuclear MedicineChang Gung Memorial Hospital at Linko
Head and Neck Oncology

DOI: 10.1245/s10434-009-0894-6

Cite this article as:
Liao, C., Huang, S., Chen, I. et al. Ann Surg Oncol (2010) 17: 1118. doi:10.1245/s10434-009-0894-6

Abstract

Background

The American Joint Committee on Cancer staging system suggests that squamous-cell carcinoma of the oral cavity (OSCC) with pN2 should be classified as stage IVA. The objective of the current study was to determine the outcome of patients with pN2 OSCC cancer according to different T status.

Methods

Between January 1996 and September 2007, a total of 270 patients with pN2 OSCC cancer were analyzed. All participants had a follow-up of at least 2 years or were censored on the date of last follow-up. The outcome measures for this study were the 5-year rates of locoregional control, distant metastases, and survival.

Results

Five-year disease-specific survival and overall survival rates in pT1 (n = 9), pT2 (n = 98), pT3 (n = 70), and pT4 (n = 93) patients were 78%, 66%, 49%, 35% (P = 0.0031), and 78%, 52%, 35%, 23% (P = 0.0001), respectively. Multivariable analysis revealed that pT3–4, level IV/V metastases, extracapsular spread, and poor differentiation were independent risk factors for 5-year disease-specific survival in the entire study cohort. Specific independent prognostic factors for 5-year disease-specific survival according to T stage were found.

Conclusions

The results of this study suggest that patients with pN2 OSCC cancer have different outcomes and prognostic factors according to their T status. In the light of these findings, treatment strategies may be quite different.

Copyright information

© Society of Surgical Oncology 2010