Annals of Surgical Oncology

, Volume 17, Issue 4, pp 1106–1110

Microscopic Evaluation of Lymph-Node-Bearing Tissue in Early-Stage Cervical Cancer: A Dual-Institution Review

Authors

    • Division of Gynecologic Oncology, Department of Obstetrics and GynecologyUniversity of Louisville Medical Center
  • Lisa Abaid
    • Division of Gynecologic OncologyUniversity of North Carolina Medical Center at Chapel Hill
  • Ricardo dos Reis
    • Hospital de Clinicas de Porto Alegre, Gynecologic Oncology ServiceUniversidade Federal do Rio Grande do Sul
  • Michael Frumovitz
    • Department of Gynecologic OncologyThe University of Texas M. D. Anderson Cancer Center
  • Paola A. Gehrig
    • Division of Gynecologic OncologyUniversity of North Carolina Medical Center at Chapel Hill
  • Chad Livasy
    • Division of Gynecologic PathologyUniversity of North Carolina Medical Center at Chapel Hill
  • Russell R. Broaddus
    • Department of PathologyThe University of Texas M. D. Anderson Cancer Center
  • Pedro T. Ramirez
    • Department of Gynecologic OncologyThe University of Texas M. D. Anderson Cancer Center
Gynecologic Oncology

DOI: 10.1245/s10434-009-0870-1

Cite this article as:
Milam, M.R., Abaid, L., Reis, R.d. et al. Ann Surg Oncol (2010) 17: 1106. doi:10.1245/s10434-009-0870-1

Abstract

Objective

We compared two different methods of microscopic lymph node examination of cervical cancer radical hysterectomy specimens to ascertain which method translates into higher nodal counts and improved detection of nodal metastasis, at M. D. Anderson Cancer Center (MDACC) and the University of North Carolina (UNC).

Methods

We retrospectively reviewed the records of 155 patients with early-stage cervical cancer who underwent open radical hysterectomy and pelvic lymph node dissection from 2000 to 2006. At MDACC lymph nodes were grossly dissected from submitted adipose tissue surgical specimens and then microscopically examined. At UNC, grossly detected lymph nodes and the remaining adipose tissue were microscopically examined. Data regarding clinicopathologic features and lymph node dissection were available for all patients.

Results

No differences in stage, grade or histology were noted between the two centers. The median age and body mass index were both higher at MDACC (40 versus 36 years of age; 28 versus 26 mg/m2; P < 0.05) The median lymph node count was lower at MDACC (16 versus 23; P = 0.001). By multivariate analysis, UNC evaluation was associated with higher total lymph node count (P = 0.001). However, no significant difference was noted between institutions in proportion of patients with nodal metastases (MDACC 20.3%; UNC 13.5%; P = 0.47).

Conclusion

The UNC method of microscopically examining the entire adipose tissue sample may be associated with higher nodal count at open radical hysterectomy. Higher nodal count, however, may not translate into increased identification of nodal metastases.

Copyright information

© Society of Surgical Oncology 2009