Annals of Surgical Oncology

, Volume 16, Issue 12, pp 3340–3349

Survival Data Justifies Resection for Pancreatic Metastases

  • Oliver Strobel
  • Thilo Hackert
  • Werner Hartwig
  • Frank Bergmann
  • Ulf Hinz
  • Moritz N. Wente
  • Stefan Fritz
  • Lutz Schneider
  • Markus W. Büchler
  • Jens Werner
Pancreatic Tumors

DOI: 10.1245/s10434-009-0682-3

Cite this article as:
Strobel, O., Hackert, T., Hartwig, W. et al. Ann Surg Oncol (2009) 16: 3340. doi:10.1245/s10434-009-0682-3

Abstract

Background

Pancreatic metastases are uncommon and little is known about the oncologic outcome after resection or prognostic parameters. This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors.

Methods

From a prospective database, all consecutive resections performed at our institution for pancreatic metastases between October 2001 and July 2008 were identified. Clinicopathological details, perioperative, and follow-up results were analyzed. Uni- and multivariate analysis were performed to identify parameters associated with overall and disease-free survival.

Results

Forty-four resections were performed for pancreatic metastases. Primary tumors included 31 (70%) renal cell carcinomas (RCC) and 13 other primary tumors. Morbidity was 33% and mortality 4.4%. Pancreatic metastases occurred after a median interval of 6.9 years after resection of the primary tumor. Twenty-five patients (57%) had additional extrapancreatic disease. With a median follow-up of 32.1 months, overall 3- and 5-year survivals were 70.2% and 56.8%, disease-free 3- and 5-year survivals were 37.2% and 33%, respectively. Patients with isolated pancreatic metastases had an overall 3- and 5-year survival of 85.6% and 74.9%. Additional extrapancreatic disease, a disease-free interval of less than 36 months, and non-RCC entity were associated with shorter overall survival. Previous recurrence, non-RCC primary tumors, and a disease-free interval of less than 36 months were associated with shorter disease-free survival.

Conclusions

Resection for pancreatic metastases can be performed safely and with good follow-up results and can be recommended as part of an interdisciplinary treatment. Especially in patients with isolated pancreatic metastases, long-term survival can be expected.

Copyright information

© Society of Surgical Oncology 2009

Authors and Affiliations

  • Oliver Strobel
    • 1
  • Thilo Hackert
    • 1
  • Werner Hartwig
    • 1
  • Frank Bergmann
    • 2
  • Ulf Hinz
    • 1
  • Moritz N. Wente
    • 1
  • Stefan Fritz
    • 1
  • Lutz Schneider
    • 1
  • Markus W. Büchler
    • 1
  • Jens Werner
    • 1
  1. 1.Department of General SurgeryUniversity of HeidelbergHeidelbergGermany
  2. 2.Institute of PathologyUniversity of HeidelbergHeidelbergGermany