False-Negative Sentinel Node Biopsy
- Omgo E. Nieweg MD, PhD
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The concept of the orderly progression of lymph node metastases is exciting and appeals to the surgical frame of mind. The momentum of the practice of lymphatic mapping may cause people to get carried away by their enthusiasm. It is thus important to keep an open eye for developments that may not live up to the expectations, and therefore, the paper from the Italian Melanoma Intergroup in this issue deserves attention. An important purpose of the study of 1313 patients with melanoma was to determine the ability of sentinel node biopsy to identify involved lymph node basins. The false-negative rate was found to be 14.4%; this high rate was obtained despite a meticulous technique and a comprehensive quality control program.1 High false-negative rates have been reported before but have rarely caused a stir.
For patients with melanoma, there has long been consensus on the principal aspects of the technique of lymphatic mapping. The combination of preoperative lymphoscintigraphy and intraope ...
- Testori A, De Salvo GL, Montesco MC, et al. Clinical considerations on sentinel node biopsy in melanoma from an Italian multicentric study on 1313 patients (SOLISM-IMI). Ann Surg Oncol. (in press). DOI:10.1245/s10434-008-0273-8.
- Gershenwald JE, Thompson W, Mansfield PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999;17:976–83.
- Morton DL, Thompson JF, Essner R, et al. Immediate versus delayed lymphadectomy in the management of primary melanoma. N Engl J Med. 2006;355:1307–17. CrossRef
- Morton DL, Wen D-R, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127:392–9.
- Nieweg OE, Tanis PJ, De Vries JDH, Kroon BBR. Sensitivity of sentinel node biopsy in melanoma. J Surg Oncol. 2001;78:223–4. CrossRef
- Van der Ploeg IMC, Valdés Olmos RA, Nieweg OE, et al. The additional value of SPECT/CT in lymphatic mapping in breast cancer and melanoma. J Nucl Med. 2007;48:1756–60. CrossRef
- Leijte JAP, Van der Ploeg IMC, Valdés Olmos RA, Nieweg OE, Horenblas S. Visualization of tumor-blockage and rerouting of lymphatic drainage in penile cancer patients using SPECT/CT. J Nucl Med. (in press).
- Van der Ploeg IMC, Nieweg OE, Van Rijk MC, Valdés Olmos RA, Kroon BBR. Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: a systematic review and meta-analysis of the literature. Eur J Surg Oncol. 2008;34:1277–84.
- Kapteijn BAE, Nieweg OE, Valdés Olmos RA, et al. Reproducibility of lymphoscintigraphy for lymphatic mapping in patients with cutaneous melanoma. J Nucl Med. 1996;37:972–5.
- Tanis PJ, Valdés Olmos RA, Muller SH, Nieweg OE. Lymphatic mapping in patients with breast carcinoma: reproducibility of lymphoscintigraphic results. Radiology. 2003;228:546–51. CrossRef
- De Kanter AY, Van Geel AN, Paul MA, et al. Controlled introduction of the sentinel node biopsy in breast cancer in a multi-centre setting: the role of a coordinator for quality control. Eur J Surg Oncol. 2000;26:652–6. CrossRef
- Wright FC, Walker J, Law CH, McCready DR. Outcomes after localized axillary node recurrence in breast cancer. Ann Surg Oncol. 2003;10:1054–8. CrossRef
- Martini L, Brandani P, Chiarugi C, Reali UM. First recurrence analysis of 840 cutaneous melanomas: a proposal for a follow-up schedule. Tumori. 1994;80:188–97.
- Doting MH, Hoekstra HJ, Plukker JT, et al. Is sentinel node biopsy beneficial in melanoma patients? A report on 200 patients with cutaneous melanoma. Eur J Surg Oncol. 2003;28:673–8. CrossRef
- Vuylsteke RJ, van Leeuwen PA, Muller MG, et al. Clinical outcome of stage I/II melanoma patients after selective sentinel lymph node dissection: long-term follow-up results. J Clin Oncol. 2003;21:1057–65. CrossRef
- Estourgie SH, Nieweg OE, Valdés Olmos RA, Hoefnagel CA, Kroon BBR. Review and evaluation of sentinel node procedures in 250 melanoma patients with a median follow-up of 6 years. Ann Surg Oncol. 2003;10:681–8. CrossRef
- Fincher TR, McCarty TM, Fisher TL, et al. Patterns of recurrence after sentinel lymph node biopsy for cutaneous melanoma. Am J Surg. 2003;186:675–81. CrossRef
- Yee VS, Thompson JF, McKinnon JG, et al. Outcome in 846 cutaneous melanoma patients from a single center after a negative sentinel node biopsy. Ann Surg Oncol. 2005;12:429–39. CrossRef
- Zogakis TG, Essner R, Wang HJ, et al. Melanoma recurrence patterns after negative sentinel lymphadenectomy. Arch Surg. 2005;140:865–71. CrossRef
- False-Negative Sentinel Node Biopsy
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Annals of Surgical Oncology
Volume 16, Issue 8 , pp 2089-2091
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- 1. Department of Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands